UniProt Accession

 G45IP_HUMAN; Q8TAE8; Q8IVM3; Q8TE51; Q969P9; Q9BSM6 

Genbank Protein ID

 AJ429498; AF479749; AF475095; BC004944; BC013039; BC013027; BC069200; AJ295986; AF147080 

Genbank Nucleotide ID

 CAD22344.1; AAL85877.1; AAM10639.1; AAH04944.1; AAH13039.2; AAH13027.2; AAH69200.1; CAC82499.1 

Protein Name

 Growth arrest and DNA damage-inducible proteins-interacting protein 1 

Protein Synonyms/Alias

 CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein 

Gene Name

 GADD45GIP1 

Gene Synonyms/Alias

 PLINP1; PRG6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	LGPRYAAKQFARYGA	ubiquitination	[1, 2, 3]
127	HIAECMAKMPQMIVN	ubiquitination	[2, 3]
184	ELLQDLEKKERKRLK	ubiquitination	[2, 3]
185	LLQDLEKKERKRLKE	ubiquitination	[2, 3]

Reference

 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. 

Sequence Annotation

 MOTIF 184 200 Nuclear localization signal (Potential).  

Keyword

 Cell cycle; Coiled coil; Complete proteome; Host-virus interaction; Mitochondrion; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR018472; Damage-induce-interacting_prot. 

Pfam

 PF10147; CR6_interact 

SMART

  

PROSITE

  

PRINTS