| Tag | Content |
|---|
| CPLM ID | CPLM-003529 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nitrogen regulation protein NR(II) |
Protein Synonyms/Alias | |
Gene Name | glnL |
Gene Synonyms/Alias | glnR; ntrB; b3869; JW3840 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 142 | RGLAHEIKNPLGGLR | acetylation | [1] | | 157 | GAAQLLSKALPDPSL | acetylation | [1] | | 169 | PSLLEYTKVIIEQAD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it, while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB. |
Sequence Annotation | DOMAIN 5 78 PAS.
DOMAIN 136 349 Histidine kinase.
BINDING 329 329 ATP (By similarity).
MOD_RES 139 139 Phosphohistidine; by autocatalysis. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Kinase; Nitrogen fixation; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MATGTQPDAG QILNSLINSI LLIDDNLAIH YANPAAQQLL AQSSRKLFGT PLPELLSYFS 60
LNIELMQESL EAGQGFTDNE VTLVIDGRSH ILSVTAQRMP DGMILLEMAP MDNQRRLSQE 120
QLQHAQQVAA RDLVRGLAHE IKNPLGGLRG AAQLLSKALP DPSLLEYTKV IIEQADRLRN 180
LVDRLLGPQL PGTRVTESIH KVAERVVTLV SMELPDNVRL IRDYDPSLPE LAHDPDQIEQ 240
VLLNIVRNAL QALGPEGGEI ILRTRTAFQL TLHGERYRLA ARIDVEDNGP GIPPHLQDTL 300
FYPMVSGREG GTGLGLSIAR NLIDQHSGKI EFTSWPGHTE FSVYLPIRK 349 |
Gene Ontology | GO:0005622; C:intracellular; IDA:EcoCyc. GO:0016020; C:membrane; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004721; F:phosphoprotein phosphatase activity; IDA:EcoCyc. GO:0000155; F:phosphorelay sensor kinase activity; IDA:EcoCyc. GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW. GO:0046777; P:protein autophosphorylation; IMP:EcoCyc. GO:0051171; P:regulation of nitrogen compound metabolic process; IMP:EcoCyc. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |