UniProt Accession

 GHITM_HUMAN; Q9H3K2; A8K9Z9; D3DWE0; O95894; Q5VT95; Q9H0P2 

Genbank Protein ID

 AB009685; AF131820; AF060923; AL136713; AY358824; AK292864; AL603756; AC022389; CH471142; CH471142; CH471142; BC010354 

Genbank Nucleotide ID

 BAA93049.1; AAD20052.1; AAG43135.1; CAB66648.1; AAQ89183.1; BAF85553.1; CAH72660.1; CAH72660.1; EAW80367.1; EAW80368.1; EAW80369.1; AAH10354.1 

Protein Name

 Growth hormone-inducible transmembrane protein 

Protein Synonyms/Alias

 Dermal papilla-derived protein 2; Mitochondrial morphology and cristae structure 1; MICS1; Transmembrane BAX inhibitor motif-containing protein 5 

Gene Name

 GHITM 

Gene Synonyms/Alias

 DERP2; MICS1; TMBIM5; My021; UNQ244/PRO281 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	VFHPAFTKASPVVKN	ubiquitination	[1]
29	TKASPVVKNSITKNQ	ubiquitination	[1]
34	VVKNSITKNQWLLTP	ubiquitination	[1]
63	GRTGQELKEAALEPS	ubiquitination	[1, 2]
76	PSMEKIFKIDQMGRW	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. 

Sequence Annotation

  

Keyword

 Apoptosis; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 

Interpro

 IPR010539; Bax_inhibitor-1.
 IPR006214; Bax_inhibitor_1-related. 

Pfam

 PF01027; Bax1-I
 PF12811; BaxI_1 

SMART

  

PROSITE

  

PRINTS