CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014020
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 162 kDa 
Protein Synonyms/Alias
 Cep162; Protein QN1 homolog 
Gene Name
 KIAA1009 
Gene Synonyms/Alias
 C6orf84; CEP162; QN1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
908GNPSIRQKIRLKDKAubiquitination[1, 2]
Reference
 [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. 
Sequence Annotation
 MOD_RES 474 474 Phosphoserine.
 MOD_RES 475 475 Phosphoserine.
 CROSSLNK 908 908 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Microtubule; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1403 AA 
Protein Sequence
MANCSQEELD EEFEQFMKEL SDDSFENSDK TARQSKKEMK KKDTVPWWIT EDDFKDDGLL 60
GTNVSYLKTK KTSQPVMEIE EESAEKIQFL KSSGTSLLST DSLETNELVV SELNHSSLGV 120
GLDTLEEQEE KEQFFARLEK GLTSSIDYSR LNKELDSNDS THFKALHSNQ ANAELTDDEH 180
ENESKHEELA ENYSDDFEDE YVGAPLTTKD EEMPSKENSK SEKISVPKQE EEKTGMLANV 240
VLLDSLDSVA EVNLDEQDKI TPKPRCLPEM TENEMTGTGV SYGQSSSDVE ALHQAYCHIA 300
HSLGDEDKQK IESNTVEDIK SSVKGHPQEN EENSKNISTM ESDLPTVEEL MKPIRIDSFG 360
ISGFDLQPVS SEKVAERKET EFFSSLPLKM NPNILSQDSQ HVNLFFDKND ENVILQKTTN 420
ESMENSCPQV TEVTATEEHV DKMYLNILRK KITVNSSSLS QDDKINKTYR SQLSSEEEGA 480
VMGKQVPYKK ARSAPPLLKR KPQSGLYASV RSSGYGKPSS PLKMFSTLEK KTSEDIIKSK 540
NLRSISTSNQ PRKKEILSGT KLIKPAALDK PAHKTESCLS TRKKSENPTE TDSCIQFQTD 600
SLGYCGENKE KKLLMFKRVQ EAEDKWRGAQ ALIEQIKATF SEKEKELENK LEELKKQQEK 660
ELFKLNQDNY ILQAKLSSFE ETNKKQRWLH FGEAADPVTG EKLKQIQKEI QEQETLLQGY 720
QQENERLYNQ VKDLQEQNKK NEERMFKENQ SLFSEVASLK EQMHKSRFLS QVVEDSEPTR 780
NQNFTDLLAE LRMAQKEKDS LLEDIKRLKQ DKQALEVDFE KMKKERDQAK DQIAYVTGEK 840
LYEIKILEET HKQEISRLQK RLQWYAENQE LLDKDALRLR EANEEIEKLK LEIEKLKAES 900
GNPSIRQKIR LKDKAADAKK IQDLERQVKE MEGILKRRYP NSLPALILAA SAAGDTVDKN 960
TVEFMEKRIK KLEADLEGKD EDAKKSLRTM EQQFQKMKIQ YEQRLEQQEQ LLACKLNQHD 1020
SPRIKALEKE LDDIKEAHQI TVRNLEAEID VLKHQNAELD VKKNDKDDED FQSIEFQVEQ 1080
AHAKAKLVRL NEELAAKKRE IQDLSKTVER LQKDRRMMLS NQNSKGREEM SAKRAKKDVL 1140
HSSKGNANSF PGTLDSKLYQ PHTFTDSHVS EVLQENYRLK NELEGLISEK NELKMKSEAV 1200
MNQFENSMRR VKEDTAAHIA SLKASHQREI EKLLCQNAVE NSSSKVAELN RKIATQEVLI 1260
RHFQSQVNEL QSKQESLVVS EVREEILQKE ITKLLEELRE AKENHTPEMK HFVGLEKKIK 1320
QMEMRHAQRE QELQQIIQQT HQVVETEQNK EVEKWKRLAQ LKNRELEKFR TELDSILDVL 1380
RELHRQGVVV PVAFADEMNA PEY 1403 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
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PRINTS