CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018621
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AFG3-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 Afg3l1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
390DMFAMARKHAPCILFacetylation[1]
550RVIGGLEKKTQVLQPacetylation[2]
551VIGGLEKKTQVLQPSacetylation[3]
551VIGGLEKKTQVLQPSsuccinylation[3]
717QCREQVEKVGRRLLEacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Putative ATP-dependent protease. 
Sequence Annotation
 NP_BIND 340 347 ATP (Potential).
 ACT_SITE 567 567 By similarity.
 METAL 566 566 Zinc; catalytic (By similarity).
 METAL 570 570 Zinc; catalytic (By similarity).
 METAL 641 641 Zinc; catalytic (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Mitochondrion; Nucleotide-binding; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MLLRLVGAAG SRALAWPFSK LWRCGGCAGS GGTVWSSVRA CGIALQGHLG RCSQQLALQG 60
KLTSFSPRLY SKPPRGFEKF FKNKKNRKSA SPGNSVPPKK EPKNAGPGGD GGNRGGKGDD 120
FPWWKRMQKG EFPWDDKDFR SLAVLGAGVA AGFLYFYFRD PGKEITWKHF VQYYLARGLV 180
DRLEVVNKQF VRVIPVPGTT SERFVWFNIG SVDTFERNLE SAQWELGIEP TNQAAVVYTT 240
ESDGSFLRSL VPTLVLVSIL LYAMRRGPMG TGRGGRGGGL FSVGETTAKI LKNNIDVRFA 300
DVAGCEEAKL EIMEFVNFLK NPKQYQDLGA KIPKGAMLTG PPGTGKTLLA KATAGEANVP 360
FITVNGSEFL EMFVGVGPAR VRDMFAMARK HAPCILFIDE IDAIGRKRGR GHLGGQSEQE 420
NTLNQMLVEM DGFNSSTNVV VLAGTNRPDI LDPALTRPGR FDRQIYIGPP DIKGRSSIFK 480
VHLRPLKLDG SLSKDALSRK LAALTPGFTG ADISNVCNEA ALIAARHLSP SVQERHFEQA 540
IERVIGGLEK KTQVLQPSEK TTVAYHEAGH AVVGWFLEHA DPLLKVSIIP RGKGLGYAQY 600
LPREQFLYTR EQLFDRMCMM LGGRVAEQLF FGQITTGAQD DLRKVTQSAY AQIVQFGMSE 660
KLGQVSFDFP RQGETMVEKP YSEATAQLID EEVRCLVRSA YNRTLELLTQ CREQVEKVGR 720
RLLEKEVLEK ADMIELLGPR PFAEKSTYEE FVEGTGSLEE DTSLPEGLKD WNKGREEGGT 780
ERGLQESPV 789 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; ISA:MGI.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042407; P:cristae formation; IGI:MGI.
 GO:0008053; P:mitochondrial fusion; IGI:MGI.
 GO:0034982; P:mitochondrial protein processing; IGI:MGI.
 GO:0030163; P:protein catabolic process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR005936; FtsH.
 IPR027417; P-loop_NTPase.
 IPR011546; Pept_M41_FtsH_extracell.
 IPR000642; Peptidase_M41. 
Pfam
 PF00004; AAA
 PF06480; FtsH_ext
 PF01434; Peptidase_M41 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS