UniProt Accession

 ACSF3_MOUSE; Q3URE1; Q78IW2; Q8VC75 

Genbank Protein ID

 AK141579; BC022709 

Genbank Nucleotide ID

 BAE24747.1; AAH22709.3 

Protein Name

 Acyl-CoA synthetase family member 3, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Acsf3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
181	VYHGATEKPTEQPVE	acetylation	[1, 2]
306	KLLDYYDKHFTQPHV	acetylation	[2]
419	VTPGFEEKEGELLVR	acetylation	[1, 2]
476	RTSVDIIKTGGYKVS	acetylation	[1]
532	SLSHGDLKEWARGVL	acetylation	[2]
561	IPRNQMGKVNKKELL	acetylation	[3]
561	IPRNQMGKVNKKELL	succinylation	[3]
565	QMGKVNKKELLKQLY	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (By similarity). 

Sequence Annotation

 NP_BIND 202 210 ATP (By similarity).
 BINDING 455 455 ATP (By similarity).
 BINDING 469 469 ATP (By similarity).
 BINDING 561 561 ATP (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Fatty acid metabolism; Ligase; Lipid metabolism; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 583 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0090409; F:malonyl-CoA synthetase activity; IEA:Compara.
 GO:0006633; P:fatty acid biosynthetic process; IEA:Compara.
 GO:0090410; P:malonate catabolic process; IEA:Compara. 

Interpro

 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 

Pfam

 PF00501; AMP-binding 

SMART

  

PROSITE

 PS00455; AMP_BINDING 

PRINTS