CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022524
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Daple 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; Hook-related protein 2; HkRP2 
Gene Name
 CCDC88C 
Gene Synonyms/Alias
 DAPLE; KIAA1509 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65PTNQRINKHVNNDVNubiquitination[1]
891GKLKELEKDNRDLTKacetylation[2]
898KDNRDLTKQVTVHARacetylation[2]
1387HKEKLEEKIMDQYKFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). 
Sequence Annotation
 REGION 2026 2028 DVL1-binding (By similarity).
 MOTIF 2025 2028 PDZ-binding (Potential).
 MOD_RES 1444 1444 Phosphoserine.
 MOD_RES 1806 1806 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2028 AA 
Protein Sequence
MDVTVSELLE LFLQSPLVTW VKTFGPFGSG SQDNLTMYMD LVDGIFLNQI MLQIDPRPTN 60
QRINKHVNND VNLRIQNLTI LVRNIKTYYQ EVLQQLIVMN LPNVLMIGRD PLSGKSMEEI 120
KKVLLLVLGC AVQCERKEEF IERIKQLDIE TQAGIVAHIQ EVTHNQENVF DLQWLELPDV 180
APEELEALSR SMVLHLRRLI DQRDECTELI VDLTQERDYL QAQHPPSPIK SSSADSTPSP 240
TSSLSSEDKQ HLAVELADTK ARLRRVRQEL EDKTEQLVDT RHEVDQLVLE LQKVKQENIQ 300
LAADARSARA YRDELDSLRE KANRVERLEL ELTRCKEKLH DVDFYKARME ELREDNIILI 360
ETKAMLEEQL TAARARGDKV HELEKENLQL KSKLHDLELD RDTDKKRIEE LLEENMVLEI 420
AQKQSMNESA HLGWELEQLS KNADLSDASR KSFVFELNEC ASSRILKLEK ENQSLQSTIQ 480
GLRDASLVLE ESGLKCGELE KENHQLSKKI EKLQTQLERE KQSNQDLETL SEELIREKEQ 540
LQSDMETLKA DKARQIKDLE QEKDHLNRAM WSLRERSQVS SEARMKDVEK ENKALHQTVT 600
EANGKLSQLE FEKRQLHRDL EQAKEKGERA EKLERELQRL QEENGRLARK VTSLETATEK 660
VEALEHESQG LQLENRTLRK SLDTLQNVSL QLEGLERDNK QLDAENLELR RLVETMRFTS 720
TKLAQMEREN QQLEREKEEL RKNVDLLKAL GKKSERLELS YQSVSAENLR LQQSLESSSH 780
KTQTLESELG ELEAERQALR RDLEALRLAN AQLEGAEKDR KALEQEVAQL EKDKKLLEKE 840
AKRLWQQVEL KDAVLDDSTA KLSAVEKESR ALDKELARCR DAAGKLKELE KDNRDLTKQV 900
TVHARTLTTL REDLVLEKLK SQQLSSELDK LSQELEKVGL NRELLLQEDD SGSDTKYKIL 960
EGRNESALKT TLAMKEEKIV LLEAQMEEKA SLNRQLESEL QMLKKECETL RQNQGEGQHL 1020
QNSFKHPAGK TAASHQGKEA WGPGHKEATM ELLRVKDRAI ELERNNAALQ AEKQLLKEQL 1080
QHLETQNVTF SSQILTLQKQ SAFLQEHNTT LQTQTAKLQV ENSTLSSQSA ALTAQYTLLQ 1140
NHHTAKETEN ESLQRQQEQL TAAYEALLQD HEHLGTLHER QSAEYEALIR QHSCLKTLHR 1200
NLELEHKELG ERHGDMLKRK AELEEREKVL TTEREALQQE QRTNALAMGE NQRLRGELDR 1260
VNFLHHQLKG EYEELHAHTK ELKTSLNNAQ LELNRWQARF DELKEQHQTM DISLTKLDNH 1320
CELLSRLKGN LEEENHHLLS QIQLLSQQNQ MLLEQNMENK EQYHEEQKQY IDKLNALRRH 1380
KEKLEEKIMD QYKFYDPPPK KKNHWIGAKA LVKLIKPKKE GSRERLKSTV DSPPWQLESS 1440
DPASPAASQP LRSQAENPDT PALGSNCAEE RDAHNGSVGK GPGDLKPKRG SPHRGSLDRT 1500
DASTDLAMRS WPSELGSRTC STSATTTAPS NSTPIARHPG RTKGYNSDDN LCEPSLEFEV 1560
PNHRQYVSRP SSLESSRNTS SNSSPLNLKG SSEQLHGRSE SFSSEDLIPS RDLATLPREA 1620
STPGRNALGR HEYPLPRNGP LPQEGAQKRG TAPPYVGVRP CSASPSSEMV TLEEFLEESN 1680
RSSPTHDTPS CRDDLLSDYF RKASDPPAIG GQPGPPAKKE GAKMPTNFVA PTVKMAAPTS 1740
EGRPLKPGQY VKPNFRLTEA EAPPSVAPRQ AQPPQSLSLG RPRQAPVPPA SHAPASRSAS 1800
LSRAFSLASA DLLRASGPEA CKQESPQKLG APEALGGRET GSHTLQSPAP PSSHSLARER 1860
TPLVGKAGSS CQGPGPRSRP LDTRRFSLAP PKEERLAPLH QSATAPAIAT AGAGAAAAGS 1920
GSNSQLLHFS PAAAPAARTK PKAPPRSGEV ATITPVRAGL SLSEGDGVPG QGCSEGLPAK 1980
SPGRSPDLAP HLGRALEDCS RGSVSKSSPA SPEPGGDPQT VWYEYGCV 2028 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0030165; F:PDZ domain binding; ISS:UniProtKB.
 GO:0043621; F:protein self-association; ISS:UniProtKB.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
 GO:0031648; P:protein destabilization; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
 GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR008636; HOOK/CCDC88. 
Pfam
 PF05622; HOOK 
SMART
  
PROSITE
  
PRINTS