UniProt Accession

 GABT_RAT; P50554; O70539; Q66HM1 

Genbank Protein ID

 U29701; D87839; BC081787 

Genbank Nucleotide ID

 AAA70415.1; BAA25570.1; AAH81787.1 

Protein Name

 4-aminobutyrate aminotransferase, mitochondrial 

Protein Synonyms/Alias

 (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT; 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform 

Gene Name

 Abat 

Gene Synonyms/Alias

 Gabat 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
47	DYDGPLMKTEVPGPR	acetylation	[1]
142	PPENFVDKLRESLMS	acetylation	[1]
142	PPENFVDKLRESLMS	methylation	[2]
235	THSKAIHKIDIPSFD	acetylation	[1]
252	IAPFPRLKYPLEEFV	acetylation	[1]
357	ADVMSFSKKMMTGGF	acetylation	[1]
452	PDEAIRNKLILIARN	acetylation	[1]
470	VLGGCGDKSIRFRPT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] A method for the comprehensive proteomic analysis of membrane proteins.
 Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd.
 Nat Biotechnol. 2003 May;21(5):532-8. [PMID: 12692561] 

Functional Description

 Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. 

Sequence Annotation

 MOD_RES 318 318 N6-acetyllysine (By similarity).
 MOD_RES 357 357 N6-(pyridoxal phosphate)lysine.
 DISULFID 163 166 By similarity.
 DISULFID 321 321 Interchain (By similarity).  

Keyword

 Acetylation; Aminotransferase; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Neurotransmitter degradation; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 500 AA 

Protein Sequence

Gene Ontology

 GO:0032144; C:4-aminobutyrate transaminase complex; ISS:UniProtKB.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0047298; F:(S)-3-amino-2-methylpropionate transaminase activity; IEA:EC.
 GO:0003867; F:4-aminobutyrate transaminase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
 GO:0032145; F:succinate-semialdehyde dehydrogenase binding; ISS:UniProtKB.
 GO:0048148; P:behavioral response to cocaine; ISS:UniProtKB.
 GO:0007620; P:copulation; IMP:RGD.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IC:UniProtKB.
 GO:0007626; P:locomotory behavior; IMP:RGD.
 GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
 GO:0042135; P:neurotransmitter catabolic process; IC:UniProtKB.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0045471; P:response to ethanol; IDA:RGD.
 GO:0001666; P:response to hypoxia; IMP:RGD.
 GO:0010039; P:response to iron ion; IDA:RGD.
 GO:0035094; P:response to nicotine; IMP:RGD. 

Interpro

 IPR004631; 4NH2But_aminotransferase_euk.
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00202; Aminotran_3 

SMART

  

PROSITE

 PS00600; AA_TRANSFER_CLASS_3 

PRINTS