CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022130
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Teneurin-2 
Protein Synonyms/Alias
 Ten-2; Protein Odd Oz/ten-m homolog 2; Tenascin-M2; Ten-m2; Teneurin transmembrane protein 2; Ten-2, soluble form; Ten-2 intracellular domain; Ten-2 ICD 
Gene Name
 TENM2 
Gene Synonyms/Alias
 KIAA1127; ODZ2; TNM2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321ETRHFLFKTSSGSTPubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. 
Sequence Annotation
 DOMAIN 1 375 Teneurin N-terminal.
 DOMAIN 575 603 EGF-like 1.
 DOMAIN 598 634 EGF-like 2.
 DOMAIN 636 668 EGF-like 3.
 DOMAIN 669 701 EGF-like 4.
 DOMAIN 702 735 EGF-like 5.
 DOMAIN 738 766 EGF-like 6.
 DOMAIN 769 797 EGF-like 7.
 DOMAIN 808 841 EGF-like 8.
 REPEAT 1272 1316 NHL 1.
 REPEAT 1342 1386 NHL 2.
 REPEAT 1401 1452 NHL 3.
 REPEAT 1474 1501 NHL 4.
 REPEAT 1530 1573 NHL 5.
 REPEAT 1583 1602 YD 1.
 REPEAT 1619 1639 YD 2.
 REPEAT 1682 1701 YD 3.
 REPEAT 1702 1724 YD 4.
 REPEAT 1895 1914 YD 5.
 REPEAT 1936 1954 YD 6.
 REPEAT 1955 1975 YD 7.
 REPEAT 1982 1999 YD 8.
 REPEAT 2000 2021 YD 9.
 REPEAT 2022 2039 YD 10.
 REPEAT 2042 2062 YD 11.
 REPEAT 2065 2085 YD 12.
 REPEAT 2093 2113 YD 13.
 REPEAT 2119 2136 YD 14.
 REPEAT 2137 2163 YD 15.
 REPEAT 2165 2178 YD 16.
 REPEAT 2179 2202 YD 17.
 REPEAT 2205 2225 YD 18.
 REPEAT 2226 2246 YD 19.
 REPEAT 2248 2268 YD 20.
 REPEAT 2280 2300 YD 21.
 REPEAT 2302 2322 YD 22.
 REPEAT 2348 2389 YD 23.
 CARBOHYD 443 443 N-linked (GlcNAc...) (Potential).
 CARBOHYD 482 482 N-linked (GlcNAc...) (Potential).
 CARBOHYD 925 925 N-linked (GlcNAc...) (Potential).
 CARBOHYD 948 948 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1267 1267 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1616 1616 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1712 1712 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1749 1749 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1773 1773 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1807 1807 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1892 1892 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1993 1993 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2197 2197 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2337 2337 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2648 2648 N-linked (GlcNAc...) (Potential).
 DISULFID 576 586 By similarity.
 DISULFID 580 591 By similarity.
 DISULFID 593 602 By similarity.
 DISULFID 611 622 By similarity.
 DISULFID 624 633 By similarity.
 DISULFID 640 651 By similarity.
 DISULFID 645 656 By similarity.
 DISULFID 658 667 By similarity.
 DISULFID 672 683 By similarity.
 DISULFID 677 688 By similarity.
 DISULFID 690 699 By similarity.
 DISULFID 710 723 By similarity.
 DISULFID 725 734 By similarity.
 DISULFID 739 749 By similarity.
 DISULFID 743 754 By similarity.
 DISULFID 756 765 By similarity.
 DISULFID 770 780 By similarity.
 DISULFID 774 785 By similarity.
 DISULFID 787 796 By similarity.
 DISULFID 810 820 By similarity.
 DISULFID 814 829 By similarity.
 DISULFID 831 840 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Cell projection; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; EGF-like domain; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane; Nucleus; Polymorphism; Postsynaptic cell membrane; Reference proteome; Repeat; Repressor; Signal-anchor; Synapse; Synaptosome; Transcription; Transcription regulation; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2774 AA 
Protein Sequence
MDVKDRRHRS LTRGRCGKEC RYTSSSLDSE DCRVPTQKSY SSSETLKAYD HDSRMHYGNR 60
VTDLIHRESD EFPRQGTNFT LAELGICEPS PHRSGYCSDM GILHQGYSLS TGSDADSDTE 120
GGMSPEHAIR LWGRGIKSRR SSGLSSRENS ALTLTDSDNE NKSDDENGRP IPPTSSPSLL 180
PSAQLPSSHN PPPVSCQMPL LDSNTSHQIM DTNPDEEFSP NSYLLRACSG PQQASSSGPP 240
NHHSQSTLRP PLPPPHNHTL SHHHSSANSL NRNSLTNRRS QIHAPAPAPN DLATTPESVQ 300
LQDSWVLNSN VPLETRHFLF KTSSGSTPLF SSSSPGYPLT SGTVYTPPPR LLPRNTFSRK 360
AFKLKKPSKY CSWKCAALSA IAAALLLAIL LAYFIAMHLL GLNWQLQPAD GHTFNNGIRT 420
GLPGNDDVAT MPSGGKVPWS LKNSSIDSGE AEVGRRVTQE VPPGVFWRSQ IHISQPQFLK 480
FNISLGKDAL FGVYIRRGLP PSHAQYDFME RLDGKEKWSV VESPRERRSI QTLVQNEAVF 540
VQYLDVGLWH LAFYNDGKDK EMVSFNTVVL DSVQDCPRNC HGNGECVSGV CHCFPGFLGA 600
DCAKAACPVL CSGNGQYSKG TCQCYSGWKG AECDVPMNQC IDPSCGGHGS CIDGNCVCSA 660
GYKGEHCEEV DCLDPTCSSH GVCVNGECLC SPGWGGLNCE LARVQCPDQC SGHGTYLPDT 720
GLCSCDPNWM GPDCSVEVCS VDCGTHGVCI GGACRCEEGW TGAACDQRVC HPRCIEHGTC 780
KDGKCECREG WNGEHCTIGR QTAGTETDGC PDLCNGNGRC TLGQNSWQCV CQTGWRGPGC 840
NVAMETSCAD NKDNEGDGLV DCLDPDCCLQ SACQNSLLCR GSRDPLDIIQ QGQTDWPAVK 900
SFYDRIKLLA GKDSTHIIPG ENPFNSSLVS LIRGQVVTTD GTPLVGVNVS FVKYPKYGYT 960
ITRQDGTFDL IANGGASLTL HFERAPFMSQ ERTVWLPWNS FYAMDTLVMK TEENSIPSCD 1020
LSGFVRPDPI IISSPLSTFF SAAPGQNPIV PETQVLHEEI ELPGSNVKLR YLSSRTAGYK 1080
SLLKITMTQS TVPLNLIRVH LMVAVEGHLF QKSFQASPNL AYTFIWDKTD AYGQRVYGLS 1140
DAVVSVGFEY ETCPSLILWE KRTALLQGFE LDPSNLGGWS LDKHHILNVK SGILHKGTGE 1200
NQFLTQQPAI ITSIMGNGRR RSISCPSCNG LAEGNKLLAP VALAVGIDGS LYVGDFNYIR 1260
RIFPSRNVTS ILELRNKEFK HSNNPAHKYY LAVDPVSGSL YVSDTNSRRI YRVKSLSGTK 1320
DLAGNSEVVA GTGEQCLPFD EARCGDGGKA IDATLMSPRG IAVDKNGLMY FVDATMIRKV 1380
DQNGIISTLL GSNDLTAVRP LSCDSSMDVA QVRLEWPTDL AVNPMDNSLY VLENNVILRI 1440
TENHQVSIIA GRPMHCQVPG IDYSLSKLAI HSALESASAI AISHTGVLYI TETDEKKINR 1500
LRQVTTNGEI CLLAGAASDC DCKNDVNCNC YSGDDAYATD AILNSPSSLA VAPDGTIYIA 1560
DLGNIRIRAV SKNKPVLNAF NQYEAASPGE QELYVFNADG IHQYTVSLVT GEYLYNFTYS 1620
TDNDVTELID NNGNSLKIRR DSSGMPRHLL MPDNQIITLT VGTNGGLKVV STQNLELGLM 1680
TYDGNTGLLA TKSDETGWTT FYDYDHEGRL TNVTRPTGVV TSLHREMEKS ITIDIENSNR 1740
DDDVTVITNL SSVEASYTVV QDQVRNSYQL CNNGTLRVMY ANGMGISFHS EPHVLAGTIT 1800
PTIGRCNISL PMENGLNSIE WRLRKEQIKG KVTIFGRKLR VHGRNLLSID YDRNIRTEKI 1860
YDDHRKFTLR IIYDQVGRPF LWLPSSGLAA VNVSYFFNGR LAGLQRGAMS ERTDIDKQGR 1920
IVSRMFADGK VWSYSYLDKS MVLLLQSQRQ YIFEYDSSDR LLAVTMPSVA RHSMSTHTSI 1980
GYIRNIYNPP ESNASVIFDY SDDGRILKTS FLGTGRQVFY KYGKLSKLSE IVYDSTAVTF 2040
GYDETTGVLK MVNLQSGGFS CTIRYRKIGP LVDKQIYRFS EEGMVNARFD YTYHDNSFRI 2100
ASIKPVISET PLPVDLYRYD EISGKVEHFG KFGVIYYDIN QIITTAVMTL SKHFDTHGRI 2160
KEVQYEMFRS LMYWMTVQYD SMGRVIKREL KLGPYANTTK YTYDYDGDGQ LQSVAVNDRP 2220
TWRYSYDLNG NLHLLNPGNS VRLMPLRYDL RDRITRLGDV QYKIDDDGYL CQRGSDIFEY 2280
NSKGLLTRAY NKASGWSVQY RYDGVGRRAS YKTNLGHHLQ YFYSDLHNPT RITHVYNHSN 2340
SEITSLYYDL QGHLFAMESS SGEEYYVASD NTGTPLAVFS INGLMIKQLQ YTAYGEIYYD 2400
SNPDFQMVIG FHGGLYDPLT KLVHFTQRDY DVLAGRWTSP DYTMWKNVGK EPAPFNLYMF 2460
KSNNPLSSEL DLKNYVTDVK SWLVMFGFQL SNIIPGFPRA KMYFVPPPYE LSESQASENG 2520
QLITGVQQTT ERHNQAFMAL EGQVITKKLH ASIREKAGHW FATTTPIIGK GIMFAIKEGR 2580
VTTGVSSIAS EDSRKVASVL NNAYYLDKMH YSIEGKDTHY FVKIGSADGD LVTLGTTIGR 2640
KVLESGVNVT VSQPTLLVNG RTRRFTNIEF QYSTLLLSIR YGLTPDTLDE EKARVLDQAR 2700
QRALGTAWAK EQQKARDGRE GSRLWTEGEK QQLLSTGRVQ GYEGYYVLPV EQYPELADSS 2760
SNIQFLRQNE MGKR 2774 
Gene Ontology
 GO:0030054; C:cell junction; ISS:UniProtKB.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0043197; C:dendritic spine; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0030175; C:filopodium; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0016605; C:PML body; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0050839; F:cell adhesion molecule binding; IDA:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0005102; F:receptor binding; IDA:UniProtKB.
 GO:0007411; P:axon guidance; IDA:UniProtKB.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IDA:UniProtKB.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR008969; CarboxyPept-like_regulatory.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR022385; Rhs_assc_core.
 IPR009471; Ten_N.
 IPR006530; YD. 
Pfam
 PF06484; Ten_N 
SMART
 SM00181; EGF 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS51125; NHL
 PS51361; TENEURIN_N 
PRINTS