CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xin actin-binding repeat-containing protein 2 
Protein Synonyms/Alias
 Beta-xin; Cardiomyopathy-associated protein 3; L-NAME-induced actin cytoskeletal protein 
Gene Name
 Xirp2 
Gene Synonyms/Alias
 Cmya3; Xin2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1109HEVTTVKKEETIHGDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Protects actin filaments from depolymerization (By similarity). 
Sequence Annotation
 REPEAT 306 321 Xin 1.
 REPEAT 341 356 Xin 2.
 REPEAT 381 396 Xin 3.
 REPEAT 418 433 Xin 4.
 REPEAT 456 471 Xin 5.
 REPEAT 496 511 Xin 6.
 REPEAT 534 549 Xin 7.
 REPEAT 572 587 Xin 8.
 REPEAT 606 621 Xin 9.
 REPEAT 640 655 Xin 10.
 REPEAT 677 692 Xin 11.
 REPEAT 713 728 Xin 12.
 REPEAT 744 759 Xin 13.
 REPEAT 782 797 Xin 14.
 REPEAT 820 835 Xin 15.
 REPEAT 859 874 Xin 16.
 REPEAT 892 907 Xin 17.
 REPEAT 930 945 Xin 18.
 REPEAT 965 980 Xin 19.
 REPEAT 1004 1019 Xin 20.
 REPEAT 1040 1055 Xin 21.
 REPEAT 1077 1092 Xin 22.
 REPEAT 1115 1130 Xin 23.
 REPEAT 1152 1167 Xin 24.
 REPEAT 1186 1201 Xin 25.
 REPEAT 1217 1232 Xin 26.
 REPEAT 1254 1269 Xin 27.
 REPEAT 1289 1304 Xin 28.
 MOD_RES 1930 1930 Phosphothreonine.
 MOD_RES 1935 1935 Phosphoserine.  
Keyword
 Actin-binding; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3302 AA 
Protein Sequence
MARYQAAVSR GDTRSFSANV MEESDLCTVP GGLAKMKRQF EKDEMTSTCN AFSEYQYQHE 60
SRSEQEAIHN RQEIRRNEEE VSKGHRTDVF KAEMMSHLEK HTEETNQASQ FRQYVQETVI 120
DTPEDEEIPK VSTKILKEQF EKTAQENFLY SDKETTTPAK CIKIENDSEE TLKPSSAMGT 180
SSYTSARQSK ETSTSSYSNH SLTSTILAQE KGTPSGKMEE FPPPPPDVFQ TPMDVTAFSQ 240
SPEFPSPPRR LPMPRDVYSK QRNLYELNRL YRHIHPELRK NLEKDYISEV SEIVSSHINS 300
GNSISAGVQQ ARYVFENTND SSQKDLSSER ENLEWDEILK GEVQSIRWIF ENQPLDSINQ 360
GFTDEAYTSK GIADQELIAG GDVKYTTWMF ETQPIDALGV PSAGTEENTE KIPELAKGDV 420
CTARWMFETR PLDSMNKMHE WEDETASTFI KDITGGDVKT VRYMFETQQL DQLGQLHSVD 480
EMNLLQLRSE LKEIKGNVKR SIKCFETQPL YVIRDGSGQM LEIKTVQRED IEKGDVRTAR 540
WMFETQPLDT IKQDITEIKV VRGISMEENV KGEVGRARWL FETQPLEKIK EESGEAVLKT 600
EAVVGIDVSK KCWMFETQPL DTLKQSPDTE SVSPEERIGG DVKTTKHLLE TLPIEALKDS 660
PDVGKLQKIT ASEEEKGDVK HQKWVFETQR LEDIREDKKE YTQTVKLEAV DRGHVKNYTH 720
IFESNNLIKV DASHQIEVEG VTRGTVELNK SLFETTPLYA IQDHLGKYHQ VKTVQQEEIV 780
RGDVRSCRWL FETRPIDQFD ESLHKFQIIR GISAQEIQAG NVKSARWLFE TQPLDSIKYF 840
SNVEETDSKT EQSTDIVKGD VKTCKWLFET QPMESLYEKA SLMTNSEDIH KGDVRTCMWL 900
FETQPLDAIK NDSEATVKLQ TVKQEEIQGG DVRTACLLFE TENLDNIQGG EGKETKPVEM 960
DIESGDVSGM KYKFENQSLD SISCSSENVL NKIKTLKIED IQKGNVLNCR WLFENQPIDM 1020
IKENQEGDGL VKTVTDIQGG DVRKGCFIFE TFSLDEIKDE SDVISTRQTN TEEVIKGDVK 1080
SYKMLFETQP LYAIQDQEGF YHEVTTVKKE ETIHGDVRGT RWLFETKPLD SINASEDVYI 1140
IKSVTQEDIQ KGDVSSVRYR FETQPLDMIS DKSHNIMPTI DHIQGGNVQM NKQLFESEGG 1200
DKKNYVRTVS INEIQKGNVK TSTWLFETHS IDELGEVSTY ENIKTVTQED VQKGDVKQAV 1260
WLFENQTLDS IKELDESDTK ITKEEIPPSD VKTTTWLFET TPIHEFNETR IEKEEIIGKS 1320
IKETLEDLYS QRVVEAPGII IEADEVGDVR MAKYKLMNQR TPEIQKEEVI RADLGNIMMN 1380
LLSQRDCTKK EIFISEEEKG NVNFTKTQLL NRSMEFHAEK EEIVRGDVKQ AIQKLFSEER 1440
CAKRGILIQE DEKGDVNMTI YCLLHENAGD KTKREDILGG DVRRTIHNLL SSASNDKISE 1500
RTKIDASERG NVQFFTTCIE TGALDYLKQL QTGSNETLTA RKQEGEEEII GGDVEGTKFL 1560
LKKRQSSIER TVSETDIIPG DVRNTVKVFM TEPQSASFKT AKEEIVKGDL KSTLNSLNQA 1620
MNQKVVAKTE DIMKDDKAAI LKSLKESGGR QKEHKQSASI SSDIGQAIEC LEKATNTRTE 1680
ILKKELILDD LKTSLRSLKE EQYSFKEVGK QGMVKDVLGF SERQELGIHP AAVQREKKSL 1740
LQPVPGPCEP AIRQQAGPGP LDEATQKSCH RSLTEERTEA NLPKAPKGTV KIVIDREQNN 1800
DALEKSLRKM SNSEHRAMKN VLDMGDRRGV WTESKECLCS DDHMSKYVSA SMSRKKSLKT 1860
KESENVRESK DDVSSTQSVD KTFRKQQTQN CELGKDHQKS QFQDSYAKNQ KNTQNISMSA 1920
ETQSYRPDPT QHPVSNPAGE TLEMTRDFQK QALIRQEKQN SNKDMRKNDM GLQPLPVGKD 1980
AHSAPGVTVS GKNHKRTQAP DKKQRIDVCL ESQDFLMKTN TSKELKMAME RSFNPVNLYP 2040
DCGVKENEDA LPPPSPPPPP PSNASSEIEF PLPPPPPIML LPEKNEFPPS SPTEKSRAEL 2100
ESLPTLPLPP PPGDEKSDQE CLPTSLPPPP PTAPSQPAHL LSSSVLEHHS EAFLQQYSRK 2160
ETLDSHQLHS QAKILTGKSP PPTLPKPKLP ERIKAKMSQD SPSGELERSL SDVEIKTTLS 2220
KDQKSSLVAE SREHTEAKQE VFRKSLGRKQ LSISSANSLS QTVPEIPAPK EKQTAPLVKS 2280
HSFPSGSEQQ SPKPYMRKFK TPLMIAEEKY RQQREELEKQ RRESSCHSII KTETQHRSLS 2340
EKEKETELQK AAEAMSTPRK DSDFTRAQPN LEPKSKAVIA SECSESQLST ASALTVATER 2400
LQHVLAASDD KLTLRREGTQ NSSDTLQSKT ACEINQSHKE CRTEQTFEQH VEKLPFPQTK 2460
PISPSFKVKT IRLPALDHTL TETDLSSERR VKQSEIDVQT STKEMNKEIK KTEVSTQCDN 2520
KQSVAEKYFQ LPKTEKRVTV QMPKDYAAKS HQSKLQTVPK KHGGLGEFDR GNVLGREGKN 2580
QDSSMSSTKE SRVIVERKQE HLQDQSVPRL VQQKIIGESL DSRVQNFQQT QTQTSRIEHK 2640
ELSQPYSEKK CLRDKDKQQK QVSSNTDDSK QEITQKQSSF SSVRESQQDG EKCAINILEF 2700
LRKREELQQI LSRVKQFEAD SNKSGLKTFQ TLLNIAPVWL ISEEKREYGV RVAMENNLEK 2760
VKEEIIHIKT QAEEMLVHCE HVIRTAMMAS QTGKQKDKPT NLNEMPLKVS NVNLSSHKGT 2820
EQKESKIVEE KLASRQVATH SEAATHNPAK TYQEAKGDDS KMAPPSLKTR PPSPTFITIE 2880
STARRAETST KSELSQSPKN NSCVEPLPRR PMEHTSRLPR TSTSPSPPRS RSEQLVRLKD 2940
TTARLAKGTI PCSPGTPVPV VEKRSEVVMS PATLRRQIKI ESRGGDSPPT ITIPVSVNHH 3000
VVSGSFRESV DAQEAVKKTE KTETYVHKDK KNSVSSAMPE TESYDAVEII RKVEGPHLSE 3060
HRERFEATNQ TVQMAEHFLN GHENEVNRWF REFENGPVFG AKTERRAYAN GEINHNMKQE 3120
SHTFCKEEFG LESSETANFT GFSYRHPREH RAKAPATQPR VHSEARALNE HFLSVDAFDS 3180
QIVESQVATS SSRSSEAGRS GFDFKHAPPT YEDVIAGHIL DIADSPTNLR RNFQKTWQES 3240
ERVFKSVGYE TSDAHATEMS RAFQEELAFL SETVGPRQGN LHNLSKDGLS NGVPRSRPAE 3300
FS 3302 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR012510; Actin-binding_Xin_repeat. 
Pfam
 PF08043; Xin 
SMART
  
PROSITE
 PS51389; XIN 
PRINTS