UniProt Accession

 BAX_MOUSE; Q07813 

Genbank Protein ID

 L22472; BC018228; BC053380 

Genbank Nucleotide ID

 AAA03622.1; AAH18228.1; AAH53380.1 

Protein Name

 Apoptosis regulator BAX 

Protein Synonyms/Alias

  

Gene Name

 Bax 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
57	PPQDASTKKLSECLR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. 

Sequence Annotation

 MOTIF 59 73 BH3.
 MOTIF 98 118 BH1.
 MOTIF 150 165 BH2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0097144; C:BAX complex; ISS:UniProtKB.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IDA:MGI.
 GO:0005757; C:mitochondrial permeability transition pore complex; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0015267; F:channel activity; ISS:UniProtKB.
 GO:0008289; F:lipid binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IMP:MGI.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:MGI.
 GO:0097296; P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:MGI.
 GO:0006309; P:apoptotic DNA fragmentation; ISS:UniProtKB.
 GO:0001783; P:B cell apoptotic process; IGI:MGI.
 GO:0001782; P:B cell homeostasis; IMP:MGI.
 GO:0002358; P:B cell homeostatic proliferation; IMP:MGI.
 GO:0002352; P:B cell negative selection; IGI:MGI.
 GO:0001974; P:blood vessel remodeling; IGI:MGI.
 GO:0071310; P:cellular response to organic substance; IDA:MGI.
 GO:0034644; P:cellular response to UV; IGI:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0006922; P:cleavage of lamin involved in execution phase of apoptosis; ISS:UniProtKB.
 GO:0045136; P:development of secondary sexual characteristics; IMP:MGI.
 GO:0010248; P:establishment or maintenance of transmembrane electrochemical gradient; ISS:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
 GO:0009566; P:fertilization; IGI:MGI.
 GO:0007281; P:germ cell development; IGI:MGI.
 GO:0035234; P:germ cell programmed cell death; IMP:MGI.
 GO:0006687; P:glycosphingolipid metabolic process; IMP:MGI.
 GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
 GO:0021854; P:hypothalamus development; IMP:MGI.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IMP:MGI.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:MGI.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IGI:MGI.
 GO:0001822; P:kidney development; IGI:MGI.
 GO:0035108; P:limb morphogenesis; IGI:MGI.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; ISS:UniProtKB.
 GO:0008053; P:mitochondrial fusion; ISS:UniProtKB.
 GO:0002262; P:myeloid cell homeostasis; IGI:MGI.
 GO:0048147; P:negative regulation of fibroblast proliferation; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IGI:MGI.
 GO:0032091; P:negative regulation of protein binding; ISS:UniProtKB.
 GO:0051402; P:neuron apoptotic process; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0030264; P:nuclear fragmentation involved in apoptotic nuclear change; IDA:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IGI:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0060058; P:positive regulation of apoptotic process involved in mammary gland involution; IMP:MGI.
 GO:0002904; P:positive regulation of B cell apoptotic process; IGI:MGI.
 GO:0048087; P:positive regulation of developmental pigmentation; IGI:MGI.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; ISS:UniProtKB.
 GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.
 GO:0032461; P:positive regulation of protein oligomerization; ISS:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:MGI.
 GO:0048597; P:post-embryonic camera-type eye morphogenesis; IGI:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0001844; P:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IMP:MGI.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IGI:MGI.
 GO:0051726; P:regulation of cell cycle; IGI:MGI.
 GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0006808; P:regulation of nitrogen utilization; IGI:MGI.
 GO:0043497; P:regulation of protein heterodimerization activity; IEA:Compara.
 GO:0043496; P:regulation of protein homodimerization activity; ISS:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:MGI.
 GO:0032976; P:release of matrix enzymes from mitochondria; ISS:UniProtKB.
 GO:0001101; P:response to acid; IDA:MGI.
 GO:0048678; P:response to axon injury; IMP:MGI.
 GO:0010332; P:response to gamma radiation; IMP:MGI.
 GO:0009651; P:response to salt stress; IGI:MGI.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:1990009; P:retinal cell apoptotic process; ISS:UniProtKB.
 GO:0046666; P:retinal cell programmed cell death; IMP:MGI.
 GO:0060011; P:Sertoli cell proliferation; IGI:MGI.
 GO:0048515; P:spermatid differentiation; IMP:MGI.
 GO:0001777; P:T cell homeostatic proliferation; IMP:MGI.
 GO:0006927; P:transformed cell apoptotic process; ISS:UniProtKB.
 GO:0060068; P:vagina development; IGI:MGI. 

Interpro

 IPR026304; BAX.
 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR020728; Bcl2_BH3_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3 

PRINTS

 PR01862; BCL2FAMILY.