UniProt Accession

 MOSC2_HUMAN; Q969Z3; B2D0R5; D3DTB3; Q0JSK7; Q5VT67; Q5VXC7; Q7L317; Q9H066; Q9NWU0 

Genbank Protein ID

 AL136931; AM393631; EU567145; AL606726; AL359353; AL606726; AL359353; AL606726; AL359353; AL359353; AL606726; AL359353; AL606726; AL359353; AL606726; CH471100; CH471100; BC011973; BC015829; BC016859; AK000612 

Genbank Nucleotide ID

 CAB66865.1; CAL38507.1; ACB21048.1; CAH71878.1; CAH71878.1; CAH71879.1; CAH71879.1; CAH71880.1; CAH71880.1; CAH70303.1; CAH70303.1; CAH70304.1; CAH70304.1; CAH70306.1; CAH70306.1; EAW93293.1; EAW93294.1; AAH11973.1; AAH15829.2; AAH16859.1; BAA91287.1 

Protein Name

 MOSC domain-containing protein 2, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial amidoxime reducing component 2; mARC2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2 

Gene Name

 MARC2 

Gene Synonyms/Alias

 MOSC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	QQVGTVAKLWIYPVK	ubiquitination	[1, 2]
138	DQLVLPSKQPSSNKL	ubiquitination	[3]
156	RIFGLDIKGRDCGNE	ubiquitination	[1, 2, 4]
166	DCGNEAAKWFTNFLK	ubiquitination	[1, 2, 4]
173	KWFTNFLKTEAYRLV	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 

Sequence Annotation

 DOMAIN 188 334 MOSC.  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Molybdenum; Oxidoreductase; Peroxisome; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0030151; F:molybdenum ion binding; IDA:UniProtKB.
 GO:0043546; F:molybdopterin cofactor binding; IDA:UniProtKB.
 GO:0008940; F:nitrate reductase activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0051410; P:detoxification of nitrogen compound; NAS:UniProtKB.
 GO:0042126; P:nitrate metabolic process; IDA:UniProtKB. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS