UniProt Accession

 E9PW16_MOUSE; E9PW16 

Genbank Protein ID

 AC140073 

Genbank Nucleotide ID

  

Protein Name

 Beta-adrenergic receptor kinase 1 

Protein Synonyms/Alias

  

Gene Name

 Adrbk1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
344	GLACDFSKKRPHASV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 408 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004703; F:G-protein coupled receptor kinase activity; IDA:MGI.
 GO:0002029; P:desensitization of G-protein coupled receptor protein signaling pathway; IMP:MGI.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.
 GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IGI:MGI.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000239; GPCR_kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase
 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50132; RGS 

PRINTS

 PR00717; GPCRKINASE.