UniProt Accession

 DHPR_MOUSE; Q8BVI4; Q3TT09; Q9D0K4 

Genbank Protein ID

 AK011351; AK078123; AK159107; AK161660; AK166694; BC002107 

Genbank Nucleotide ID

 BAB27559.1; BAC37135.1; BAE34823.1; BAE36516.1; BAE38951.1; AAH02107.1 

Protein Name

 Dihydropteridine reductase 

Protein Synonyms/Alias

 HDHPR; Quinoid dihydropteridine reductase 

Gene Name

 Qdpr 

Gene Synonyms/Alias

 Dhpr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	QVTADVGKLLGDQKV	ubiquitination	[1]
99	AKSKSLFKNCDMMWK	acetylation	[2]
124	HLATKHLKEGGLLTL	ubiquitination	[1]
135	LLTLAGAKAALDGTP	ubiquitination	[1]
233	QVVTTDGKTELTPAY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases (By similarity). 

Sequence Annotation

 NP_BIND 11 35 NADP (By similarity).
 ACT_SITE 147 147 Proton acceptor (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome; Tetrahydrobiopterin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004155; F:6,7-dihydropteridine reductase activity; ISS:UniProtKB.
 GO:0070404; F:NADH binding; IEA:Compara.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0010044; P:response to aluminum ion; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0010288; P:response to lead ion; IEA:Compara.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS