CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018345
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RUN and FYVE domain-containing protein 2 
Protein Synonyms/Alias
 Rab4-interacting protein related 
Gene Name
 RUFY2 
Gene Synonyms/Alias
 KIAA1537; RABIP4R 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53ARTGPATKDPTAVERubiquitination[1, 2]
294IEELAIAKNNIIKLQubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 86 218 RUN.
 ZN_FING 589 647 FYVE-type.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 655 AA 
Protein Sequence
MGGDCLGLGG SRGRHGNAPP PLFRPVPARV LRHSGRGLEV PRRPGARTGP ATKDPTAVER 60
ANLLNMAKLS IKGLIESALS FGRTLDSDYP PLQQFFVVME HCLKHGLKVR KSFLSYNKTI 120
WGPLELVEKL YPEAEEIGAS VRDLPGLKTP LGRARAWLRL ALMQKKMADY LRCLIIQRDL 180
LSEFYEYHAL MMEEEGAVIV GLLVGLNVID ANLCVKGEDL DSQVGVIDFS MYLKNEEDIG 240
NKERNVQIAA ILDQKNYVEE LNRQLNSTVS SLHSRVDSLE KSNTKLIEEL AIAKNNIIKL 300
QEENHQLRSE NKLILMKTQQ HLEVTKVDVE TELQTYKHSR QGLDEMYNEA RRQLRDESQL 360
RQDVENELAV QVSMKHEIEL AMKLLEKDIH EKQDTLIGLR QQLEEVKAIN IEMYQKLQGS 420
EDGLKEKNEI IARLEEKTNK ITAAMRQLEQ RLQQAEKAQM EAEDEDEKYL QECLSKSDSL 480
QKQISQKEKQ LVQLETDLKI EKEWRQTLQE DLQKEKDALS HLRNETQQII SLKKEFLNLQ 540
DENQQLKKIY HEQEQALQEL GNKLSESKLK IEDIKEANKA LQGLVWLKDK EATHCKLCEK 600
EFSLSKRKHH CRNCGEIFCN ACSDNELPLP SSPKPVRVCD SCHALLIQRC SSNLP 655 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR004012; Run.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF02759; RUN 
SMART
 SM00064; FYVE
 SM00593; RUN 
PROSITE
 PS50826; RUN
 PS50178; ZF_FYVE 
PRINTS