UniProt Accession

 CDC26_HUMAN; Q8NHZ8 

Genbank Protein ID

 AF503918; AL449305; BC042534; BC066300 

Genbank Nucleotide ID

 AAM34207.1; CAI10967.1; AAH42534.1; AAH66300.1 

Protein Name

 Anaphase-promoting complex subunit CDC26 

Protein Synonyms/Alias

 Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog 

Gene Name

 CDC26 

Gene Synonyms/Alias

 ANAPC12; C9orf17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	INDRIGYKPQPKPNN	acetylation	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. 

Sequence Annotation

 MOD_RES 42 42 Phosphoserine.
 MOD_RES 82 82 Phosphoserine.  

Keyword

 3D-structure; Cell cycle; Cell division; Coiled coil; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 85 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007094; P:mitotic spindle assembly checkpoint; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB. 

Interpro

 IPR018860; APC_suCDC26. 

Pfam

 PF10471; APC_CDC26 

SMART

  

PROSITE

  

PRINTS