UniProt Accession

 D6RCE4_HUMAN; D6RCE4 

Genbank Protein ID

 AC107050; AC110761 

Genbank Nucleotide ID

  

Protein Name

 Protocadherin Fat 1 

Protein Synonyms/Alias

  

Gene Name

 FAT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	PAWEVRYKIVSGDSE	ubiquitination	[1]
101	CFLRIRTKGGNTAIL	ubiquitination	[1, 2]
121	DHYTLIVKALEKNTN	ubiquitination	[1]
125	LIVKALEKNTNVEAR	ubiquitination	[1]
189	GEFYYSFKDRTDMFA	ubiquitination	[1, 2]
216	RLDYLETKLYEMEIL	ubiquitination	[1, 2]
339	YNLTLQAKDKGTPPQ	ubiquitination	[1]
341	LTLQAKDKGTPPQFS	ubiquitination	[1, 2, 3]
351	PPQFSSVKVIHVTSP	ubiquitination	[2]
366	QFKAGPVKFEKDVYR	ubiquitination	[1, 3]
369	AGPVKFEKDVYRAEI	ubiquitination	[1, 3]
390	NTPVVMVKAIPAYSH	ubiquitination	[1, 2, 3]
403	SHLRYVFKSTPGKAK	ubiquitination	[1, 2]
427	ISILEPVKRQQAAHF	ubiquitination	[1, 2, 3]
452	ASTKVLVKVLGANSN	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Calcium; Complete proteome; Membrane; Reference proteome; Transmembrane. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:Compara.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0007163; P:establishment or maintenance of cell polarity; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 

Interpro

 IPR002126; Cadherin.
 IPR015919; Cadherin-like. 

Pfam

 PF00028; Cadherin 

SMART

 SM00112; CA 

PROSITE

 PS50268; CADHERIN_2 

PRINTS

 PR00205; CADHERIN.