| Tag | Content |
|---|
| CPLM ID | CPLM-014277 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 1 |
Protein Synonyms/Alias | |
Gene Name | Tbc1d1 |
Gene Synonyms/Alias | Kiaa1108; Tbc1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1179 | KTNSSLRKQNLDLLE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells. |
Sequence Annotation | DOMAIN 238 398 PID.
DOMAIN 887 1081 Rab-GAP TBC.
MOD_RES 146 146 Phosphoserine.
MOD_RES 229 229 Phosphoserine; by PKB/AKT1.
MOD_RES 231 231 Phosphoserine; by AMPK.
MOD_RES 489 489 Phosphoserine; by PKB/AKT1.
MOD_RES 497 497 Phosphoserine.
MOD_RES 499 499 Phosphothreonine; by PKB/AKT1.
MOD_RES 501 501 Phosphoserine.
MOD_RES 519 519 Phosphoserine.
MOD_RES 521 521 Phosphoserine.
MOD_RES 559 559 Phosphoserine.
MOD_RES 564 564 Phosphoserine (By similarity).
MOD_RES 565 565 Phosphoserine.
MOD_RES 567 567 Phosphoserine (By similarity).
MOD_RES 579 579 Phosphoserine (By similarity).
MOD_RES 590 590 Phosphothreonine.
MOD_RES 608 608 Phosphoserine.
MOD_RES 621 621 Phosphoserine; by PKB/AKT1.
MOD_RES 660 660 Phosphoserine.
MOD_RES 661 661 Phosphoserine.
MOD_RES 697 697 Phosphoserine; by PKB/AKT1.
MOD_RES 698 698 Phosphoserine.
MOD_RES 699 699 Phosphoserine.
MOD_RES 700 700 Phosphoserine; by AMPK.
MOD_RES 1028 1028 Phosphoserine.
MOD_RES 1039 1039 Phosphotyrosine.
MOD_RES 1218 1218 Phosphothreonine. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1255 AA |
Protein Sequence | MEAITFTARK HPFPNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SGQCSKKEPR 60
TKQVRLWVSP SGLRCEPDLE KSQPWDPLIC SSIFECKPQR VHKLIHNSHD PSYFACLIKE 120
DAAHRQSLCY VFKADDQTKV PEIISSIRQA GKIARQEELR CPSEFDDTFA KKFEVLFCGR 180
VTVAHKKAPP ALIDECIEKF NHVSCGRRTD WEAPTGQPSA PGPRPMRKSF SQPGLRSLAF 240
RKEFQDASLR SSTFSSFDND IENHLIGGHN VVQPTDMEEN RTMLFTIGQS EVYLISPDTK 300
KIALEKNFKE ISFCSQGIRH VDHFGFICRE CSGGGSGGFH FVCYVFQCTN EALVDEIMMT 360
LKQAFTVAAV QQTAKAPAQL CEGCPLQGLH KLCERIEGMN SSKTKLELQK HLTTLTNQEQ 420
ATIFEEVQKL RPRNEQRENE LIISFLRCLY EEKQKEHSHT GEPKQTLQVA AENIGSDLPP 480
SASRFRLDSL KNRAKRSLTE SLESILSRGN KARGLQDHSA SVDLDSSTSS TLSNTSKELS 540
MGDKEAFPVS ETSFKLLGSS DDLSSDSEGH IAEESALLSP QQAFRRRANT LSHFPVECPA 600
PPEPAQSSPG VSQRKLMRYH SVSTETPHER NVDHLPGGES QGCPGQPSAP PPPRLNPSAS 660
SPNFFKYLKH NSSGEQSGNA VPKSVSYRNA LRKKLHSSSS VPNFLKFLAP VDENNTCDFK 720
NTNRDFESKA NHLGDTDGTP VKTRRHSWRQ QIFLRVATPQ KACDSPSRYE DYSELGELPP 780
RSPLEPVCED GPFGPVQEEK RKTSRELREL WKKAILQQIL LLRMEKENQK LQASENDLLN 840
KRLKLDYEEI TPCLKEVTTV WEKMLSTPGR SKIKFDMEKV HSAVGQGVPR HHRGEIWKFL 900
AEQFHLKHPF PSKQQPKDVP YKELLKKLTS QQHAILIDLG RTFPTHPYFS AQLGAGQLSL 960
YNILKAYSLL DQEVGYCQGL SFVAGILLLH MSEEEAFKML KFLMFDMGLR KQYRPDMIIL 1020
QIQMYQLSRL LHDYHRDLYN HLEEHEIGPS LYAAPWFLTV FASQFPLGFV ARVFDMIFLQ 1080
GSEVIFKVAL SLLGSHKPLI LQHENLETIV DFIKNTLPNL GLVQMEKTIS QVFEMDIAKQ 1140
LQAYEVEYHV LQEELIESSP LSDNQRMEKL EKTNSSLRKQ NLDLLEQLQV ANARIQSLEA 1200
TVEKLLTSES KLKQAALTLE VERSALLQMV EELRRQSARP STPEPDCTQL EPTGD 1255 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. GO:0032880; P:regulation of protein localization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |