CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022013
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hermansky-Pudlak syndrome 4 protein 
Protein Synonyms/Alias
 Light-ear protein homolog 
Gene Name
 HPS4 
Gene Synonyms/Alias
 KIAA1667 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
207LPPSLTAKVLLHRTAubiquitination[1]
710FSLSGKAKQKLLKHGubiquitination[1]
715KAKQKLLKHGVNLL*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May function in the pathway of organelle biogenesis. 
Sequence Annotation
 MOD_RES 355 355 Phosphoserine.  
Keyword
 Albinism; Alternative splicing; Complete proteome; Hermansky-Pudlak syndrome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 708 AA 
Protein Sequence
MAPLCSLARW NYFFLYDGSK VKEEGDPTRA GICYFYPSQT LLDQQELLCG QIAGVVRCVS 60
DISDSPPTLV RLRKLKFAIK VDGDYLWVLG CAVELPDVSC KRFLDQLVGF FNFYNGPVSL 120
AYENCSQEEL STEWDTFIEQ ILKNTSDLHK IFNSLWNLDQ TKVEPLLLLK AARILQTCQR 180
SPHILAGCIL YKGLIVSTQL PPSLTAKVLL HRTAPQEQRL PTGEDAPQEH GKWMLWSFKN 240
RVTHQNPNGA ALPPNVQIIP VFVTKEEAIS LHEFPVEQMT RSLASPAGLQ DGSAQHHPKG 300
GSTSALKENA TGHVESMAWT TPDPTSPDEA CPDGRKENGC LSGHDLESIR PAGLHNSARG 360
EVLGLSSSLG KELVFLQEEL DLSEIHIPEA QEVEMASGHF AFLHVPVPDG RAPYCKASLS 420
ASSSLEPTPP EDTAISSLRP PSAPEMLTQH GAQEQLEDHP GHSSQAPIPR ADPLPRRTRR 480
PLLLPRLDPG QRGNKLPTGE QGLDEDVDGV CESHAAPGLE CSSGSANCQG AGPSADGISS 540
RLTPAESCMG LVRMNLYTHC VKGLVLSLLA EEPLLGDSAA IEEVYHSSLA SLNGLEVHLK 600
ETLPRDEAAS TSSTYNFTHY DRIQSLLMAN LPQVATPQDR RFLQAVSLMH SEFAQLPALY 660
EMTVRNASTA VYACCNPIQE TYFQQLAPAA RSSGFPNPQD GAFSLSGKAK QKLLKHGVNL 720
L 721 
Gene Ontology
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0042827; C:platelet dense granule; IDA:UniProtKB.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0007599; P:hemostasis; TAS:UniProtKB.
 GO:0007040; P:lysosome organization; IDA:UniProtKB.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0048075; P:positive regulation of eye pigmentation; TAS:UniProtKB.
 GO:0050821; P:protein stabilization; IPI:UniProtKB.
 GO:0006605; P:protein targeting; IDA:UniProtKB. 
Interpro
 IPR026091; HPS4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS