UniProt Accession

 RWDD1_HUMAN; Q9H446; A8K3W2; A8MT24; Q9Y313; Q9Y6B3 

Genbank Protein ID

 AF132958; AF092134; AK290727; AK301089; AL121953; CH471051; CH471051; BC015802 

Genbank Nucleotide ID

 AAD27733.1; AAD40376.1; BAF83416.1; BAG62691.1; CAC14427.1; EAW48221.1; EAW48222.1; AAH15802.1 

Protein Name

 RWD domain-containing protein 1 

Protein Synonyms/Alias

 DRG family-regulatory protein 2 

Gene Name

 RWDD1 

Gene Synonyms/Alias

 DFRP2; CGI-24; PTD013 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
157	NFLNWKAKFDAELLE	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Protects DRG2 from proteolytic degradation (By similarity). 

Sequence Annotation

 DOMAIN 10 114 RWD.
 REGION 142 197 Interaction with DRG2 (By similarity).
 MOD_RES 144 144 Phosphothreonine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR006575; RWD-domain.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF05773; RWD 

SMART

 SM00591; RWD 

PROSITE

 PS50908; RWD 

PRINTS