CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016521
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein EMSY 
Protein Synonyms/Alias
  
Gene Name
 Emsy 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
517SLATLGGKIISSNIVacetylation[1]
584QTVPAGAKPAIITATacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). As part of a H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). 
Sequence Annotation
 DOMAIN 16 114 ENT.
 REGION 1 442 Interaction with BRCA2 (By similarity).
 REGION 118 122 Interaction with ZMYND11 (By similarity).
 MOD_RES 171 171 Phosphothreonine (By similarity).
 MOD_RES 173 173 Phosphoserine (By similarity).
 MOD_RES 1085 1085 Phosphoserine (By similarity).
 CARBOHYD 192 192 O-linked (GlcNAc).  
Keyword
 Alternative splicing; Chromatin regulator; Complete proteome; DNA damage; DNA repair; Glycoprotein; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1264 AA 
Protein Sequence
MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKEKKDLLG ELSKVLSIST 60
ERHRAEVRRA VNDERLTTIA HKMNLSLYLG ERPSYSMSGP NSSSEWSIEG RRLVPLMPRL 120
VPQTAFTVTA NAVANAAVQH NASLPVPAET ASKDGVSCSD EDEKPRKRRR TNSSSSSPVV 180
LKEVPKAVVP VSKTITVPVS GSPKMSNIMQ SIANSLPPHM SPVKITFTKP STQTTNTTTQ 240
KVIIVTTSPS STFVPNILSK SHNYAAVTKL VPTSVIASTT QKPPVVITAS QASLVTSSSN 300
GNSSSTSSPI SSTVAVTTVV SSTPSVVMST VAQGVSTSAI KVASTRLPSP KSLVSGPTQI 360
LAQFPKQHQQ SPKQQLQQVQ QQTQQPVAQP SSVSQQQQPQ QSALPPGIKP TIQIKQESGV 420
KIITQQVQPS KILPKPVTAT LPTSSNSPIM VVSSNGAIMT TKLVTTPTGT QATYTRPTVS 480
PSLGRVATTP GAATYVKTTS GSIITVVPKS LATLGGKIIS SNIVSGTTTK ITTIPMTSKP 540
NVIVVQKTTG KGTTIQGLPG KNVVTTLLNA GGEKTLQTVP AGAKPAIITA TRPITKMIVT 600
QPKGIGSAVQ PAAKIIPTKI VYGQQGKTQV LIKPKPVTFQ ATVVSEQTRQ LVTETLQQAS 660
RVADASNSSA QEGKEEPQGY TDSSSSSTES SQSSQDSQPV VHVIASRRQD WSEHEIAMET 720
SPTIIYQDVS SESQSATSTI KALLELQQTT VKEKLESKPR QPTIDLSQMA VPIQMTQEKR 780
HSPESPSIAV VESELVAEYI TTVSHRSQPQ QPSQPQRTLL QHVAQSQTAT QTSVVVKSIP 840
ASSPGAITHI MQQALSSHTA FTKHSEELGT EEGEVEEMDT LDPQTGLFYR SALTQSQSTK 900
QQKLSQPQLE QTQLQVKTLQ CFQTKQKQTI HLQADQLQHK LTQMPQLSIR HQKLNPLQQE 960
QAQPKPDAQH TQHTVVAKDR QLPTLMAQPP QTVVQVLAVK TTQQLPKLQQ APNQPKIYVQ 1020
PQTPQSQMAL PSSEKQPASQ VEQPIITQGS SVTKITFEGR QPPTVTKITG GSSVPKLTSP 1080
VTSISPIQAS EKTAVSDILQ MSLMEAQIDT NVEHMVVDPP KKALATNVLT GEAGALPSTH 1140
VVVAGMTKCR ESCSSPSAVG PPLTTRKIEA AGVPTTGQFM RIQNVGQKKA EESPTEIIIQ 1200
AIPQYAIPCH SSSNVVVEPS GLLELNNFTS QQLDDDETAM EQDIDSSTED GTEPSPSQSA 1260
VERS 1264 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR005491; ENT_N. 
Pfam
 PF03735; ENT 
SMART
  
PROSITE
 PS51138; ENT 
PRINTS