UniProt Accession

 IFIT1_HUMAN; P09914; Q5T7J1; Q96QM5 

Genbank Protein ID

 X03557; BT006667; AK314588; AL353146; CH471066; BC007091; X06559 

Genbank Nucleotide ID

 CAA27244.1; AAP35313.1; BAG37163.1; CAI12379.1; EAW50136.1; AAH07091.1; CAA29802.1 

Protein Name

 Interferon-induced protein with tetratricopeptide repeats 1 

Protein Synonyms/Alias

 IFIT-1; Interferon-induced 56 kDa protein; IFI-56K; P56 

Gene Name

 IFIT1 

Gene Synonyms/Alias

 G10P1; IFI56; IFNAI1; ISG56 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
151	EEGWALLKCGGKNYE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. 

Sequence Annotation

 REPEAT 52 85 TPR 1.
 REPEAT 95 128 TPR 2.
 REPEAT 139 174 TPR 3.
 REPEAT 183 216 TPR 4.
 REPEAT 218 249 TPR 5.
 REPEAT 251 284 TPR 6.
 REPEAT 305 339 TPR 7.
 REPEAT 340 373 TPR 8.
 REPEAT 378 412 TPR 9.
 REPEAT 437 470 TPR 10.
 REGION 256 262 Interaction with the 5'-triphosphate  

Keyword

 3D-structure; Antiviral defense; Complete proteome; Cytoplasm; Host-virus interaction; Immunity; Innate immunity; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 478 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0071360; P:cellular response to exogenous dsRNA; IDA:BHF-UCL.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0019060; P:intracellular transport of viral proteins in host cell; IDA:BHF-UCL.
 GO:0050689; P:negative regulation of defense response to virus by host; IDA:BHF-UCL.
 GO:0051097; P:negative regulation of helicase activity; IDA:BHF-UCL.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
 GO:0045070; P:positive regulation of viral genome replication; IDA:BHF-UCL.
 GO:0009615; P:response to virus; IMP:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR024121; Interferon-induced_IFIT1.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1
 PF07719; TPR_2 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS