| Tag | Content |
|---|
| CPLM ID | CPLM-009100 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane protease serine 3 |
Protein Synonyms/Alias | Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein |
Gene Name | TMPRSS3 |
Gene Synonyms/Alias | ECHOS1; TADG12; UNQ323/PRO382 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | CDGVSDCKDGEDEYR | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). |
Sequence Annotation | DOMAIN 72 108 LDL-receptor class A.
DOMAIN 109 205 SRCR.
DOMAIN 217 449 Peptidase S1.
ACT_SITE 257 257 Charge relay system (By similarity).
ACT_SITE 304 304 Charge relay system (By similarity).
ACT_SITE 401 401 Charge relay system (Probable).
CARBOHYD 221 221 N-linked (GlcNAc...) (Potential).
DISULFID 73 85 By similarity.
DISULFID 79 98 By similarity.
DISULFID 92 107 By similarity.
DISULFID 129 194 By similarity.
DISULFID 142 204 By similarity.
DISULFID 207 324 By similarity.
DISULFID 242 258 By similarity.
DISULFID 338 407 By similarity.
DISULFID 370 386 By similarity.
DISULFID 397 425 By similarity. |
Keyword | Alternative splicing; Complete proteome; Deafness; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Non-syndromic deafness; Polymorphism; Protease; Reference proteome; Serine protease; Signal-anchor; Transmembrane; Transmembrane helix; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 454 AA |
Protein Sequence | MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI 60
LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF 120
TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK 180
VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH 240
LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR 300
LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA 360
AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS 420
FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT 454 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0043025; C:neuronal cell body; IEA:Compara. GO:0005044; F:scavenger receptor activity; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; NAS:UniProtKB. GO:0017080; F:sodium channel regulator activity; IDA:MGI. GO:0006883; P:cellular sodium ion homeostasis; IDA:MGI. GO:0006508; P:proteolysis; NAS:UniProtKB. GO:0007605; P:sensory perception of sound; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |