CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027703
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tight junction protein 3 
Protein Synonyms/Alias
 Tight junction protein 3, isoform CRA_b; Tight junction protein ZO-3 
Gene Name
 Tjp3 
Gene Synonyms/Alias
 mCG_12093 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
186DVLMRPLKSVLVKRRubiquitination[1]
652DSPSKIIKLDTVRVIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 904 AA 
Protein Sequence
MEELTIWEQH TATLYKDPRR GFGIAVSGGH DRASGSVVVS DVVPGGPAEG RLRTGDHIVM 60
VNGVSVENVT SAFAIQILKT CTKTANVTVK RPRRVQLPAT KASPASGHQL SDQEEADHGR 120
GYEGDSSSGS GRSWGERSRR SRAGRRGRVG SHGRRSSGGG SEANGLDLVS GYKRLPKQDV 180
LMRPLKSVLV KRRNSEEFGV KLGSQIFIKH ITESGLAARN HGLQEGDLIL QINGVSSANL 240
SLSDTRRLIE KSEGELTLLV LRDSGQFLVN IPPAVSDSDS SLMEDISDLT SELSQAPPSH 300
VPPPPLKGQR SPEDSQTDSP VETPQPRRRE RSVNSRAIAE PESPGESRYD IYRVPSRQSL 360
EDRGYSPDTR VVSFPKGASI GLRLAGGNDV GIFVSGVQAG SPADGQGIQE GDEILQVNGM 420
PFRNLTREEA VQFLLGLPPG EDMELVTQSK QDIFKKMVQS RVGDSFYIRT HFELEPSPPY 480
GLGFTRGDVF HVVDTLYPGS GPGHGHSSHG GLWLAARMGR DLREQERGVI PNQSRAEQLA 540
SLEAAQRAAG VGPGASVGSN PRAEFWRLRG LRRGTKKAST QRSREDLSAL TRQGHYPPYE 600
RVVLREASFK RPVVILGPVA DIAMKKLTTE MPEEFEIAES MSRTDSPSKI IKLDTVRVIA 660
ERDKHALLDV TPSAIERLNY VQYYPIVIFC APESRPALKA LREWLAPASR RSSRRLYAQA 720
QKLQKHSGHL FTATIPLHGT SDSWYQEVKA VIQQQQARPI WTAEDQLNSS SEDLDLPGHG 780
LAASSGDLSC DSRTNSDYED TDGEGAYTDR EGGPQDVDEE VAPTALARSS EPVWVDDHQG 840
LMGHGTTITD KWETQADSHY TQDQRRQDSM RTYKHEALRK KFTRARDVES SDDEGYDWGP 900
ATDL 904 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IGI:MGI. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR005417; ZonOcculdens.
 IPR005420; ZonOcculS3. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ 
PRINTS
 PR01597; ZONOCCLUDNS.
 PR01600; ZONOCCLUDNS3.