UniProt Accession

 IFM2_HUMAN; Q01629; Q6FH82; Q96DA8 

Genbank Protein ID

 X57351; CR541874; AC136475; BC009696 

Genbank Nucleotide ID

 CAA40625.1; CAG46672.1; AAH09696.1 

Protein Name

 Interferon-induced transmembrane protein 2 

Protein Synonyms/Alias

 Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D 

Gene Name

 IFITM2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	SVKSRDRKMVGDVTG	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 LIPID 70 70 S-palmitoyl cysteine (By similarity).
 LIPID 71 71 S-palmitoyl cysteine (By similarity).
 LIPID 104 104 S-palmitoyl cysteine (By similarity).  

Keyword

 Acetylation; Antiviral defense; Cell membrane; Complete proteome; Immunity; Innate immunity; Lipoprotein; Membrane; Palmitate; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 132 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
 GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB.
 GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
 GO:0035456; P:response to interferon-beta; IDA:UniProtKB.
 GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
 GO:0009615; P:response to virus; IDA:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR007593; Interferon-induced_TM_protein. 

Pfam

 PF04505; CD225 

SMART

  

PROSITE

  

PRINTS