CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019511
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat and FYVE domain-containing protein 2 
Protein Synonyms/Alias
 WD40- and FYVE domain-containing protein 2; Zinc finger FYVE domain-containing protein 22 
Gene Name
 WDFY2 
Gene Synonyms/Alias
 WDF2; ZFYVE22 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
232MWDIGGRKGTAIELQubiquitination[1]
388LLTSGTDKVIKLWDMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 REPEAT 22 61 WD 1.
 REPEAT 66 105 WD 2.
 REPEAT 112 150 WD 3.
 REPEAT 153 192 WD 4.
 REPEAT 197 236 WD 5.
 REPEAT 240 279 WD 6.
 REPEAT 364 399 WD 7.
 ZN_FING 281 352 FYVE-type.  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; WD repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV WLKRDSGQYW 60
PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED YNKMTPVKNY QAHQSRVTMI 120
LFVLELEWVL STGQDKQFAW HCSESGQRLG GYRTSAVASG LQFDVETRHV FIGDHSGQVT 180
ILKLEQENCT LVTTFRGHTG GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG 240
HNDRVQALSY AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ 300
MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA ITDEERAPTA 360
TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS 400 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF00400; WD40 
SMART
 SM00064; FYVE
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION
 PS50178; ZF_FYVE 
PRINTS
 PR00320; GPROTEINBRPT.