UniProt Accession

 BID_HUMAN; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86 

Genbank Protein ID

 AF042083; AF250233; AY005151; AF087891; CR456389; CR407603; AY309922; BC009197; BC022072; BC033634; BC036364 

Genbank Nucleotide ID

 AAC34365.1; AAO32633.1; AAF89091.1; AAP97190.1; CAG30275.1; CAG28531.1; AAP50259.1; AAH09197.1; AAH22072.2; AAH33634.1; AAH36364.2 

Protein Name

 BH3-interacting domain death agonist 

Protein Synonyms/Alias

 p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID 

Gene Name

 BID 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
204	LALLLAKKVASHTPS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. 

Sequence Annotation

 MOTIF 86 100 BH3.
 MOD_RES 54 54 Phosphotyrosine.
 MOD_RES 78 78 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0032592; C:integral to mitochondrial membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0005123; F:death receptor binding; TAS:ProtInc.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0090150; P:establishment of protein localization to membrane; IDA:BHF-UCL.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; TAS:ProtInc.
 GO:0034349; P:glial cell apoptotic process; IEA:Compara.
 GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:0051402; P:neuron apoptotic process; TAS:HGNC.
 GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization; TAS:Reactome.
 GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara. 

Interpro

 IPR020728; Bcl2_BH3_motif_CS.
 IPR010479; BID. 

Pfam

 PF06393; BID 

SMART

  

PROSITE

 PS01259; BH3 

PRINTS