CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A-kinase anchor protein SPHKAP 
Protein Synonyms/Alias
 SPHK1-interactor and AKAP domain-containing protein; Sphingosine kinase type 1-interacting protein 
Gene Name
 SPHKAP 
Gene Synonyms/Alias
 KIAA1678; SKIP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1380KDSVTECKQPPVSSLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. 
Sequence Annotation
 REGION 929 946 PKA-RII subunit binding domain (By  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1700 AA 
Protein Sequence
MDGNSLLSVP SNLESSRMYD VLEPQQGRGC GSSGSGPGNS ITACKKVLRS NSLLESTDYW 60
LQNQRMPCQI GFVEDKSENC ASVCFVNLDV NKDECSTEHL QQKLVNVSPD LPKLISSMNV 120
QQPKENEIVV LSGLASGNLQ ADFEVSQCPW LPDICLVQCA RGNRPNSTNC IIFEINKFLI 180
GLELVQERQL HLETNILKLE DDTNCSLSSI EEDFLTASEH LEEESEVDES RNDYENINVS 240
ANVLESKQLK GATQVEWNCN KEKWLYALED KYINKYPTPL IKTERSPENL TKNTALQSLD 300
PSAKPSQWKR EAVGNGRQAT HYYHSEAFKG QMEKSQALYI PKDAYFSMMD KDVPSACAVA 360
EQRSNLNPGD HEDTRNALPP RQDGEVTTGK YATNLAESVL QDAFIRLSQS QSTLPQESAV 420
SVSVGSSLLP SCYSTKDTVV SRSWNELPKI VVVQSPDGSD AAPQPGISSW PEMEVSVETS 480
SILSGENSSR QPQSALEVAL ACAATVIGTI SSPQATERLK MEQVVSNFPP GSSGALQTQA 540
PQGLKEPSIN EYSFPSALCG MTQVASAVAV CGLGEREEVT CSVAPSGSLP PAAEASEAMP 600
PLCGLASMEL GKEAIAKGLL KEAALVLTRP NTYSSIGDFL DSMNRRIMET ASKSQTLCSE 660
NVVRNELAHT LSNVILRHSI DEVHHKNMII DPNDNRHSSE ILDTLMESTN QLLLDVICFT 720
FKKMSHIVRL GECPAVLSKE TIRRRETEPS CQPSDPGASQ AWTKATESSS SSPLSNSHNT 780
SLVINNLVDG MYSKQDKGGV RPGLFKNPTL QSQLSRSHRV PDSSTATTSS KEIYLKGIAG 840
EDTKSPHHSE NECRASSEGQ RSPTVSQSRS GSQEAEESIH PNTQEKYNCA TSRINEVQVN 900
LSLLGDDLLL PAQSTLQTKH PDIYCITDFA EELADTVVSM ATEIAAICLD NSSGKQPWFC 960
AWKRGSEFLM TPNVPCRSLK RKKESQGSGT AVRKHKPPRL SEIKRKTDEH PELKEKLMNR 1020
VVDESMNLED VPDSVNLFAN EVAAKIMNLT EFSMVDGMWQ AQGYPRNRLL SGDRWSRLKA 1080
SSCESIPEED SEARAYVNSL GLMSTLSQPV SRASSVSKQS SCESITDEFS RFMVNQMENE 1140
GRGFELLLDY YAGKNASSIL NSAMQQACRK SDHLSVRPSC PSKQSSTESI TEEFYRYMLR 1200
DIERDSRESA SSRRSSQDWT AGLLSPSLRS PVCHRQSSMP DSRSPCSRLT VNVPIKANSL 1260
DGFAQNCPQD FLSVQPVSSA SSSGLCKSDS CLYRRGGTDH ITNMLIHETW ASSIEALMRK 1320
NKIIVDDAEE ADTEPVSGGS PSQAEKCANR LAASRMCSGP TLLVQESLDC PRKDSVTECK 1380
QPPVSSLSKT ASLTNHSPLD SKKETSSCQD PVPINHKRRS LCSREVPLIQ IETDQREACA 1440
GEPEPFLSKS SLLEEAEGHS NDKNIPDVVR GGDTAVSACQ IHSDSLDTRD VPEAEASTEA 1500
RAPDEAPNPP SSSEESTGSW TQLANEEDNP DDTSSFLQLS ERSMSNGNSS ATSSLGIMDL 1560
DIYQESMPSS PMINELVEEK KILKGQSEST EAPASGPPTG TASPQRSLLV INFDLEPECP 1620
DAELRATLQW IAASELGIPT IYFKKSQENR IEKFLDVVQL VHRKSWKVGD IFHAVVQYCK 1680
MHEEQKDGRL SLFDWLLELG 1700 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0051018; F:protein kinase A binding; IDA:UniProtKB. 
Interpro
 IPR018292; AKAP_110_C.
 IPR008382; SPHK1-interactor_AKAP_110. 
Pfam
 PF05716; AKAP_110 
SMART
  
PROSITE
  
PRINTS