UniProt Accession

 DEOB_ECOLI; P0A6K6; P07651; Q2M5T4 

Genbank Protein ID

 U14003; U00096; AP009048; X00742 

Genbank Nucleotide ID

 AAA97279.1; AAC77336.1; BAE78372.1; CAA25325.1 

Protein Name

 Phosphopentomutase 

Protein Synonyms/Alias

 Phosphodeoxyribomutase 

Gene Name

 deoB 

Gene Synonyms/Alias

 drm; thyR; b4383; JW4346 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
220	ARPFIGDKAGNFQRT	acetylation	[1, 2]
250	LQKLVDEKHGQVVSV	acetylation	[1, 2]
259	GQVVSVGKIADIYAN	acetylation	[2]
271	YANCGITKKVKATGL	acetylation	[2]
274	CGITKKVKATGLDAL	acetylation	[1, 2]
287	ALFDATIKEMKEAGD	acetylation	[1, 2, 3]
372	PVLVYGPKVKPGSLG	acetylation	[2]
393	DIGQTLAKYFGTSDM	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Phosphotransfer between the C1 and C5 carbon atoms of pentose. 

Sequence Annotation

 METAL 10 10 Manganese (By similarity).
 METAL 311 311 Manganese (By similarity).
 METAL 347 347 Manganese (By similarity).
 METAL 348 348 Manganese (By similarity).
 METAL 359 359 Manganese (By similarity).
 MOD_RES 287 287 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Isomerase; Manganese; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030145; F:manganese ion binding; IEA:HAMAP.
 GO:0008973; F:phosphopentomutase activity; IEA:HAMAP.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0043094; P:cellular metabolic compound salvage; IEA:InterPro.
 GO:0009264; P:deoxyribonucleotide catabolic process; IEA:HAMAP.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 

Interpro

 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR017850; Alkaline_phosphatase_core.
 IPR010045; DeoB.
 IPR006124; Metalloenzyme.
 IPR024052; Phosphopentomutase_DeoB_cap. 

Pfam

 PF01676; Metalloenzyme 

SMART

  

PROSITE

  

PRINTS