| Tag | Content |
|---|
| CPLM ID | CPLM-018689 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 5 |
Protein Synonyms/Alias | Carboxypeptidase Y-deficient protein 10; Vacuolar protein-targeting protein 5 |
Gene Name | VPS5 |
Gene Synonyms/Alias | GRD2; PEP10; VPT5; YOR069W; YOR29-20 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 262 | EVEENSEKFGKTKIG | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5- VPS17 subcomplex may assemble onto the membrane to promote vesicle formation. |
Sequence Annotation | DOMAIN 279 394 PX.
BINDING 320 320 Phosphatidylinositol 3-phosphate (By
BINDING 346 346 Phosphatidylinositol 3-phosphate (By
BINDING 360 360 Phosphatidylinositol 3-phosphate (By |
Keyword | Complete proteome; Cytoplasm; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 675 AA |
Protein Sequence | MDYEDNLEAP VWDELNHEGD KTQSLVSNSI ESIGQISTNE ERKDNELLET TASFADKIDL 60
DSAPEWKDPG LSVAGNPQLE EHDNSKADDL INSLAPEQDP IADLKNSTTQ FIATRESGGA 120
LFTGNANSPL VFDDTIYDAN TSPNTSKSIS GRRSGKPRIL FDSARAQRNS KRNHSLKAKR 180
TTASDDTIKT PFTDPLKKAE KENEFVEEPL DDRNERRENN EGKFTASVEK NILEQVDRPL 240
YNLPQTGANI SSPAEVEENS EKFGKTKIGS KVPPTEKAVA FKVEVKDPVK VGELTSIHVE 300
YTVISESSLL ELKYAQVSRR YRDFRWLYRQ LQNNHWGKVI PPPPEKQSVG SFKENFIENR 360
RFQMESMLKK ICQDPVLQKD KDFLLFLTSD DFSSESKKRA FLTGSGAIND SNDLSEVRIS 420
EIQLLGAEDA AEVLKNGGID AESHKGFMSI SFSSLPKYNE ADEFFIEKKQ KIDELEDNLK 480
KLSKSLEMVD TSRNTLAAST EEFSSMVETL ASLNVSEPNS ELLNNFADVH KSIKSSLERS 540
SLQETLTMGV MLDDYIRSLA SVKAIFNQRS KLGYFLVVIE NDMNKKHSQL GKLGQNIHSE 600
KFREMRKEFQ TLERRYNLTK KQWQAVGDKI KDEFQGFSTD KIREFRNGME ISLEAAIESQ 660
KECIELWETF YQTNL 675 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0005768; C:endosome; IDA:SGD. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0030905; C:retromer complex, outer shell; IPI:SGD. GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD. GO:0007154; P:cell communication; IEA:InterPro. GO:0045053; P:protein retention in Golgi apparatus; IMP:SGD. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0042147; P:retrograde transport, endosome to Golgi; IPI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |