| Tag | Content |
|---|
| CPLM ID | CPLM-013859 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative oxidoreductase GLYR1 |
Protein Synonyms/Alias | Glyoxylate reductase 1 homolog; Nuclear protein NP60 |
Gene Name | Glyr1 |
Gene Synonyms/Alias | Np60 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | KLSLSEGKVKKNMGE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (By similarity). |
Sequence Annotation | DOMAIN 8 66 PWWP.
DNA_BIND 167 179 A.T hook.
NP_BIND 270 284 NAD (By similarity).
BINDING 361 361 NAD (By similarity).
BINDING 504 504 NAD (By similarity).
MOD_RES 130 130 Phosphoserine (By similarity).
MOD_RES 166 166 Phosphoserine (By similarity).
MOD_RES 539 539 Phosphoserine (By similarity). |
Keyword | Complete proteome; DNA-binding; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 552 AA |
Protein Sequence | MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL 60
KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHTSADDKNR RNSSEERSRP 120
NSGDEKRKLS LSEGKVKKNM GEGKKRVTSG SADRGSKCLK RAQEQSPRKR GRPPKDEKDL 180
TIPESSTVKG MMAGPMAAFK WQPTASEPVK DADPHFHHFL LSQTEKPAVC YQAITKKLKI 240
CEEETGSTSI QAADSTAVNG SITPTDKKIG FLGLGLMGSG IVSNLLKMGH TVTVWNRTAE 300
KCDLFIQEGA RLGRTPAEVV STCDITFACV SDPKAAKDLV LGPSGVLQGI RPGKCYVDMS 360
TVDADTVTEL AQVIVSRGGR FLEAPVSGNQ QLSNDGMLVI LAAGDRGLYE DCSSCFQAMG 420
KTSFFLGEVG NAAKMMLIVN MVQGSFMATI AEGLTLAQVT GQSQQTLLDI LNQGQLASIF 480
LDQKCQNILQ GNFKPDFYLK YIQKDLRLAI ALGDAVNHPT PMAAAANEVY KRAKALDQSD 540
NDMSAVYRAY IH 552 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0050662; F:coenzyme binding; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0035064; F:methylated histone residue binding; ISS:UniProtKB. GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro. GO:0006098; P:pentose-phosphate shunt; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |