CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 35 
Protein Synonyms/Alias
 cDNA FLJ33886 fis, clone CTONG2007399, highly similar to WD repeat protein 35 
Gene Name
 WDR35 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24WQYRVAKKLTALEINubiquitination[1]
63DGVLDYSKTIQGTRDubiquitination[1, 2]
155QVVGELLKLERRDVWubiquitination[1, 2, 3]
245DSRALIEKVGIKDASubiquitination[1, 3]
249LIEKVGIKDASQFIEubiquitination[1, 2, 3]
274LAEAALQKLDLYTAEubiquitination[1, 2]
301KFVKRLGKLLSESMKubiquitination[1]
308KLLSESMKQAEVVGYubiquitination[2]
341LAIGLRLKLGDWFRVubiquitination[1, 2, 3, 4]
353FRVLQLLKTGSGDADubiquitination[2]
380DYFADRQKWLNAVQYubiquitination[4]
469QRGKVKGKSSEATSAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MTKTHVIAAS KEAFYTWQYR VAKKLTALEI NQITRSRKEG RERIYHVDDT PSGSMDGVLD 60
YSKTIQGTRD PICAITASDK ILIVGRESGT IQRYSLPNVG LIQKYSLNCR AYQLSLNCNS 120
SRLAIIDISG VLTFFDLDAR VTDSTGQQVV GELLKLERRD VWDMKWAKDN PDLFAMMEKT 180
RMYVFRNLDP EEPIQTSGYI CNFEDLEIKS VLLDEILKDP EHPNKDYLIN FEIRSLRDSR 240
ALIEKVGIKD ASQFIEDNPH PRLWRLLAEA ALQKLDLYTA EQAFVRCKDY QGIKFVKRLG 300
KLLSESMKQA EVVGYFGRFE EAERTYLEMD RRDLAIGLRL KLGDWFRVLQ LLKTGSGDAD 360
DSLLEQANNA IGDYFADRQK WLNAVQYYVQ GRNQERLAEC YYMLEDYEGL ENLAISLPEN 420
HKLLPIADEE AKKGSKPLRV KKLYVLSALL IEQYHEQMKN AQRGKVKGKS SEATSALAGL 480
LEEEVLSTTD RFTDNAWRGA EAYHFFILAQ RQLYEGCVDT ALKTVEKGNC QHALPQEAQS 540
LSINSGCAVY ANTVSLLRK 559 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS