UniProt Accession

 C9J7Z4_HUMAN; C9J7Z4 

Genbank Protein ID

 AC018500; AC090947 

Genbank Nucleotide ID

  

Protein Name

 tRNA-splicing endonuclease subunit Sen2 

Protein Synonyms/Alias

  

Gene Name

 TSEN2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	DIEQLYGKGYFGKGI	ubiquitination	[1]
68	YGKGYFGKGILSRSR	ubiquitination	[1, 2]
208	PTTESFEKSVREDAS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000213; F:tRNA-intron endonuclease activity; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro. 

Interpro

 IPR011856; tRNA_endonuc-like_dom.
 IPR006677; tRNA_intron_Endonuc_cat-like.
 IPR006678; tRNA_intron_Endonuc_N. 

Pfam

 PF01974; tRNA_int_endo
 PF02778; tRNA_int_endo_N 

SMART

  

PROSITE

  

PRINTS