CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028520
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Complement component C8 alpha chain 
Protein Synonyms/Alias
  
Gene Name
 C8a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
204LYYGEDEKYFRKPYNubiquitination[1]
258TVGVAPVKSPVSIEVubiquitination[1]
271EVTGSGSKASSFLNKubiquitination[1]
363VLDKEKMKTEGTTVDubiquitination[1]
537RTVIEGLKDFKAAGHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MFVVAFFGLS LVAWHPGVTA QEKVNQRVTR AVTPQAVSCQ LSDWYKWTDC FPCQDKKYRY 60
RSLLQPSKFG GTICSGDIWD EASCDSPTPC LRQAQCGQDF QCRETGRCLK RHLVCNGDND 120
CLDGSDESDC EDVRVTEDDC HQYEPIPGSE RAALGYNILT QEEAQSVYDA KYYGGQCETV 180
YNGDWRKLRY DPTCERLYYG EDEKYFRKPY NFLKYHFEAL ADTSISSEFY DDANDLFFHI 240
KNGKSHSAGV TVGVAPVKSP VSIEVTGSGS KASSFLNKLN KYNEKRYGFM RVSTKIQTAQ 300
FKMRRNNIVL DEGMLQSLME LPEQFNYGMY AKFINDYGTH YITSGTMGGI YEYVMVLDKE 360
KMKTEGTTVD EVQKCIGGGI GIGIKDSTIE GVGISGEFCE NSGDGDRDIR KKITGVEDII 420
SRVQGGSSVW GSVLTHNSSA ITYQSWGRSL KYNPVVIDFE MQPIYQLLRH TNLGPLETKR 480
QNLRRALDQY LMEFNACRCG PCFNNGEPIL DGTNCRCQCS MGRQGLACER TVIEGLKDFK 540
AAGHWSCWSS WSECRGGSQE RRRQCNNPPP KNGDQHGGDF 580 
Gene Ontology
 GO:0005579; C:membrane attack complex; IEA:InterPro.
 GO:0006955; P:immune response; IEA:InterPro. 
Interpro
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR001862; MAC_perforin.
 IPR020864; MACPF.
 IPR020863; MACPF_CS.
 IPR000884; Thrombospondin_1_rpt. 
Pfam
 PF00057; Ldl_recept_a
 PF01823; MACPF 
SMART
 SM00192; LDLa
 SM00457; MACPF
 SM00209; TSP1 
PROSITE
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS00279; MACPF_1
 PS51412; MACPF_2
 PS50092; TSP1 
PRINTS
 PR00764; COMPLEMENTC9.