CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006654
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoethanolamine transferase EptA 
Protein Synonyms/Alias
 Polymyxin resistance protein PmrC 
Gene Name
 eptA 
Gene Synonyms/Alias
 pagB; pmrC; STM4293 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
330NDNDGGCKGACDRVPacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin. 
Sequence Annotation
  
Keyword
 Antibiotic resistance; Cell inner membrane; Cell membrane; Complete proteome; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MLKRFLKRPV LGQIAWLLLF SFYIAVCLNI AFYKQVLQDL PLNSLRNVLV FISMPVVAFS 60
VVNSVLTLAS FIWLNRLLAC VFILVGAAAQ YFILTYGIII DRSMIANMMD TTPAETFALM 120
TPQMVLTLGL SGVLAAVIAF WVKIRPATPR LRSGLYRLAS VLISILLVIL VAAFFYKDYA 180
SLFRNNKQLI KALSPSNSIV ASWSWYSHQR LANLPLVRIG EDAHRNPLML KGDRKNLTIL 240
IVGETSRGDD FSLGGYPRDT NPRLAKDDVI YFPHTTSCGT ATAISVPCMF SDMPRKHYDE 300
ELAHHQEGLL DIIQRAGINV LWNDNDGGCK GACDRVPHQN VTELNLPGQC IDGECYDEVL 360
FHGLEDYIDH LKGDGVIVLH TIGSHGPTYY NRYPPQFKKF TPTCDTNEIQ NCSQEQLINT 420
YDNTVLYVDY IVDKAINLLK SHQDKFTTSL VYLSDHGESL GENGVYLHGL PYSIAPDTQK 480
HVPMLIWLSK DYQQRYQVDQ ACLQKRASTL DYSQDNLFST MLGLTGVQTT YYQAADDILQ 540
PCRRLSE 547 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. 
Interpro
 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR017850; Alkaline_phosphatase_core.
 IPR012549; DUF1705.
 IPR000917; Sulfatase. 
Pfam
 PF08019; DUF1705
 PF00884; Sulfatase 
SMART
  
PROSITE
  
PRINTS