CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033087
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tumor protein p73 
Protein Synonyms/Alias
  
Gene Name
 TP73 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
345PALGAGVKKRRHGDEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 555 AA 
Protein Sequence
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 60
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 120
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 180
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 240
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR 300
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR 360
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPP RDAQQPWPRS ASQRRDEQQP 420
QRPVHGLGVP LHSATPLPRR PQPRQDLGAL KIPEQYRMTI WRGLQDLKQG HDYSTAQQLL 480
RSSNAATISI GGSGELQRQR VMEAVHFRVR HTITIPNRGG PGGGPDEWAD FGFDLPDCKA 540
RKQPIKEEFT EAEIH 555 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:InterPro.
 GO:0051262; P:protein tetramerization; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR011615; p53_DNA-bd.
 IPR010991; p53_tetrameristn.
 IPR002117; p53_tumour_suppressor.
 IPR013761; SAM/pointed. 
Pfam
 PF00870; P53
 PF07710; P53_tetramer 
SMART
  
PROSITE
 PS00348; P53 
PRINTS
 PR00386; P53SUPPRESSR.