UniProt Accession

 B7Z1L3_HUMAN; B7Z1L3 

Genbank Protein ID

 AC004835; AK293618; CH471161 

Genbank Nucleotide ID

 BAH11549.1; EAW89881.1 

Protein Name

 Membrane-associated progesterone receptor component 1 

Protein Synonyms/Alias

 Progesterone receptor membrane component 1, isoform CRA_c; cDNA FLJ50115, moderately similar to Membrane-associated progesterone receptor component 1 

Gene Name

 PGRMC1 

Gene Synonyms/Alias

 hCG_23188 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	ILMAINGKVFDVTKG	ubiquitination	[1, 2]
102	GKVFDVTKGRKFYGP	ubiquitination	[1]
120	HHVGKLLKEGEEPTV	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Receptor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0020037; F:heme binding; IEA:InterPro. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd. 

Pfam

 PF00173; Cyt-b5 

SMART

  

PROSITE

  

PRINTS