| Tag | Content |
|---|
| CPLM ID | CPLM-016514 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lanosterol synthase |
Protein Synonyms/Alias | 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC |
Gene Name | Lss |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 367 | QEHVSRIKDYLWLGL | ubiquitination | [1] | | 433 | ENCPDYQKYYRHMRK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (By similarity). |
Sequence Annotation | REPEAT 125 166 PFTB 1.
REPEAT 484 529 PFTB 2.
REPEAT 561 601 PFTB 3.
REPEAT 613 654 PFTB 4.
ACT_SITE 233 233 Proton acceptor (By similarity).
ACT_SITE 456 456 Proton donor (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Repeat; Steroid biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 733 AA |
Protein Sequence | MTEGTCLRRR GGPYKTEPAT DLTRWRLQNE LGRQRWTYYQ AEDDPGREQT GLEAHSLGLD 60
TRSYFTDLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG GPLFLLPGLL ITCHISHISL 120
PAGYREEMVR YLRSVQLPDG GWGLHIEDKS TVFGTALNYV ALRILGIGPD DPDLVRARNV 180
LHKKGGAVAI PSWGKFWLAV LNVYSWEGLN TLFPEMWLFP EWVPAHPSTL WCHCRQVYLP 240
MSYCYATRLS ASEDPLVQSL RQELYVQDYA SIDWPAQRNN VSPDEMYTPH SWLLHVVYGL 300
LNLYERFHST SLRKWAVQML YEHIAADDCF TKCISIGPIS KTINMLVRWS VDGPSSPAFQ 360
EHVSRIKDYL WLGLDGMKMQ GTNGSQIWDT SFAIQALLEA GAHHRPEFLP CLQKAHEFLR 420
LSQVPENCPD YQKYYRHMRK GGFSFSTLDC GWIVADCTAE GLKAVLLLQN QCPSITEHIP 480
RERLCDAVDV LLSLRNADGG FATYEKKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ 540
ALKHFHEHFP DYRAAEVRET LNQGLDFCRR KQRADGSWEG SWGVCFTYGT WFGLEAFACM 600
GHTYQDGAAC AEVAQACNFL LSQQMADGGW GEDFESCEQR RYVQSARSQV HSTCWALMGL 660
MAVRHPDITA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS CAISYTSYRN IFPIWALGRF 720
SNLYPDNTLA GHI 733 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005811; C:lipid particle; IEA:Compara. GO:0000250; F:lanosterol synthase activity; IEA:EC. GO:0006695; P:cholesterol biosynthetic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |