CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039265
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Phip 
Protein Synonyms/Alias
  
Gene Name
 Phip 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1433SAAQMNGKPESSSVVacetylation[1]
1673LIVPTNVKILRRSNRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1758 AA 
Protein Sequence
VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS 60
ALAALHCGRP PESPVNYGSP PNIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120
SSVYCVTFDR TGRRIFTGSD DCLVKIWATD DGRLLATLRG HAAEISDMAV NYENTMIAAG 180
SCDKMIRVWC LRTCAPLAVL QGHSASITSL QFSPLCSGSK RYLSSTGADG TICFWLWDAG 240
TLKINPRPTK FTERPRPGVQ MICSSFSAGG MFLATGSTDH IIRVYFFGSG QPEKISELEF 300
HTDKVDSIQF SNTSNRFVSG SRDGTARIWQ FKRREWKSIL LDMATRPAGQ NLQGIEDKIT 360
KMKVTMVAWD RHESSFIPPV NNQPSESWEF LGHRIHVLTG HEDEVFVLEP HPFDPRVLFS 420
AGHDGNVIVW DLARGVKVRS YFNMIEGQGH GAVFDCKCSP DGQHFACTDS HGHLVIFGFG 480
SSSKYDKIAD QMFFHSDYRP LIRDANNFVL DEQTQQAPHL MPPPFLVDVD GNPHPSRYQR 540
LVPGRENCRE EQLIPQMGVT SSGLNQVLSQ QAIQDISPLD SMIQRLQQEQ DLRRSGEAAV 600
SSAGRLNRGS VSSTSEVHSP PNVGLRRSGQ IEGVRQMHSN APRSEIATER DLVAWSRRVV 660
VPELSAGVAS RQEEWRTAKG EEEIKSYRSE EKRKHLTVAK ENKILTVSKN HAHEHFLDLG 720
DSKKQQANQH NYRTRSALEE TPRPLEEIEN GTSSSDEGEV LAVSGGTSEE EERAWHSDGS 780
SSDYSSDYSD WTADAGINLQ PPKKVPKHKT KKQDSSSDEE EESENQKQKH IKKERKKANE 840
EKDGPTSPKK KKPKERKQKR LAVGELTENG LTLEEWLPSA WITDTLPRRC PFVPQMGDEV 900
YYFRQGHEAY VEMARKNRIY SINPKKQPWH KMELREQELM KIVGIKYEVG LPTLCCLKLA 960
FLDPDTGKLT GGSFTMKYHD MPDVIDFLVL RQQFDDAKYR RWNIGDRFRS VIDDAWWFGT 1020
IESQEPLQPE YPDSLFQCYN VCWDNGDTEK MSPWDMELIP NNAVFPEELG TSVPLTDVEC 1080
RSLIYKPLDG EWGANPRDEE CERIVGGINQ LMTLDIASAF VAPVDLQAYP MYCTVVAYPT 1140
DLSTIKQRLE NRFYRRFSSL MWEVRYIEHN TRTFNEPGSP IVKSAKFVTD LLLHFIKDQT 1200
CYNIIPLYNS MKKKVLSDSE EEEKDADVPG TSTRKRKDHQ PRRRLRNRAQ SYDIQAWRKQ 1260
CQELLNLIFQ CEDSEPFRQP VDLLEYPDYR DIIDTPMDFA TVRETLEAGN YESPMELCKD 1320
VRLIFSNSKA YTPSKRSRIY SMSLRLSAFF EEHISSVLSD YKSALRFHKR NTITKRRKRR 1380
NRSSSLSSSA ASSPERKKRI LKPQLKSEIS TSPFSIPTRS VLPRHSAAQM NGKPESSSVV 1440
RTRSNRIAVD PVVTEQPSTS AATKAFVSKT NTSAMPGKTI LENSVKHSKA LSTLSSPDQL 1500
TFSHGTKNNS AKENMEKEKP VKRKMKSSVF TKASPLPKSS AVVDQGDCKN NVLIPGTIQV 1560
NGHGGQPSKL VKRGPGRKPK VEVNTSSGEV THKKRGRKPK NLQCTTKQEN SEQNNMHPIR 1620
GDVVPSSTCS FLSETNVVKE DLLQKKSRGG RKPKRKMKTQ NLDSELIVPT NVKILRRSNR 1680
KKADDPIDEE EEFEELKGSE PHMRTRNQGR RTAFYNEDDS EEEQRQLLFE DTSLTFGTSS 1740
RGRVRKLTEK AKANLIGW 1758 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:Compara. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00439; Bromodomain
 PF00400; WD40 
SMART
 SM00297; BROMO
 SM00320; WD40 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00503; BROMODOMAIN.