| Tag | Content |
|---|
| CPLM ID | CPLM-008769 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol transfer protein PDR16 |
Protein Synonyms/Alias | PITP; Pleiotropic drug resistance protein 16; SEC14 homolog 3 |
Gene Name | PDR16 |
Gene Synonyms/Alias | SFH3; YNL231C; N1158 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 345 | EKLLYPVKSESSTV* | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover. |
Sequence Annotation | DOMAIN 135 295 CRAL-TRIO. |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Lipid droplet; Lipid transport; Membrane; Microsome; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 351 AA |
Protein Sequence | MFKRFSKKKE APEDPKNLIN IDKPIKELPA SIAIPKEKPL TGEQQKMYDE VLKHFSNPDL 60
KVYTSEKNKS EDDLKPLEEE EKAWLTRECF LRYLRATKWV LKDCIDRITM TLAWRREFGI 120
SHLGEEHGDK ITADLVAVEN ESGKQVILGY ENDARPILYL KPGRQNTKTS HRQVQHLVFM 180
LERVIDFMPA GQDSLALLID FKDYPDVPKV PGNSKIPPIG VGKEVLHILQ THYPERLGKA 240
LLTNIPWLAW TFLKLIHPFI DPLTREKLVF DEPFVKYVPK NELDSLYGGD LKFKYNHDVY 300
WPALVETARE KRDHYFKRFQ SFGGIVGLSE VDLRGTHEKL LYPVKSESST V 351 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005811; C:lipid particle; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0008526; F:phosphatidylinositol transporter activity; IDA:SGD. GO:0008654; P:phospholipid biosynthetic process; IGI:SGD. GO:0042493; P:response to drug; IGI:SGD. GO:0016126; P:sterol biosynthetic process; IGI:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |