CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear protein UKp68, isoform CRA_g 
Protein Synonyms/Alias
 Zinc finger CCCH domain-containing protein 14 
Gene Name
 ZC3H14 
Gene Synonyms/Alias
 FLJ11806; hCG_21080 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
172DTRSFILKKPKLSEEubiquitination[1]
173TRSFILKKPKLSEEVubiquitination[1, 2]
175SFILKKPKLSEEVVVubiquitination[1, 2, 3]
191PNQESGMKTADSLRVubiquitination[1, 2, 3, 4]
214RDLVQPDKPASPKFIubiquitination[1, 2]
295SELSVAQKPEKLLERubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 438 AA 
Protein Sequence
MRMSSKFPSP PLPIFLPPEP VDLGSITSSS CSLNELDNIS HLLRKISADI NEIKGMKAAI 60
LTVEANLFDL NVRVSKNEAK ISSLEVKMNE YSTTYECNRQ FEDQEEDTES QSRTTDVKII 120
GFLRNVEKGT QQRQLLSRLQ IDPVMAETLQ MSQDYYDMES MVHADTRSFI LKKPKLSEEV 180
VVAPNQESGM KTADSLRVLS GHLMQTRDLV QPDKPASPKF IVTLDGVPSP PGYMSDQEED 240
MCFEGMKPVN QTAASNKGLR GLLHPQQLHL LSRQLEDPNG SFSNAEMSEL SVAQKPEKLL 300
ERCKYWPACK NGDECAYHHP ISPCKAFPNC KFAEKCLFVH PNCKYDAKCT KPDCPFTHVS 360
RRIPVLSPKP AVAPPAPPSS SQLCRYFPAC KKMECPFYHP KHCRFNTQCT RPDCTFYHPT 420
INVPPRHALK WIRPQTSE 438 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1 
PRINTS