CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endothelin-converting enzyme 1 
Protein Synonyms/Alias
 cDNA FLJ59212, highly similar to Endothelin-converting enzyme 1 (EC 3.4.24.71) 
Gene Name
 ECE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
197RIEELRAKPLMELIEubiquitination[1]
271SRDYYLNKTENEKVLubiquitination[2]
472TEIILEIKKAFEESLubiquitination[2]
496TRKSAKEKADAIYNMubiquitination[2]
639NSSVEAFKRQTECMVubiquitination[2]
676IADNGGLKAAYRVWCubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 738 AA 
Protein Sequence
MRGVWPPPVS ALLSALGMST YKRATLDEED LVDSLSEGDA YPNGLQVNFH SPRSGQRCWA 60
ARTQVEKRLV VLVVLLAAGL VACLAALGIQ YQTRSPSVCL SEACVSVTSS ILSSMDPTVD 120
PCHDFFSYAC GGWIKANPVP DGHSRWGTFS NLWEHNQAII KHLLENSTAS VSEAERKAQV 180
YYRACMNETR IEELRAKPLM ELIERLGGWN ITGPWAKDNF QDTLQVVTAH YRTSPFFSVY 240
VSADSKNSNS NVIQVDQSGL GLPSRDYYLN KTENEKVLTG YLNYMVQLGK LLGGGDEEAI 300
RPQMQQILDF ETALANITIP QEKRRDEELI YHKVTAAELQ TLAPAINWLP FLNTIFYPVE 360
INESEPIVVY DKEYLEQIST LINTTDRCLL NNYMIWNLVR KTSSFLDQRF QDADEKFMEV 420
MYGTKKTCLP RWKFCVSDTE NNLGFALGPM FVKATFAEDS KSIATEIILE IKKAFEESLS 480
TLKWMDEETR KSAKEKADAI YNMIGYPNFI MDPKELDKVF NDYTAVPDLY FENAMRFFNF 540
SWRVTADQLR KAPNRDQWSM TPPMVNAYYS PTKNEIVFPA GILQAPFYTR SSPKALNFGG 600
IGVVVGHELT HAFDDQGREY DKDGNLRPWW KNSSVEAFKR QTECMVEQYS NYSVNGEPVN 660
GRHTLGENIA DNGGLKAAYR VWCSVRTPES SHEGLITDPH SPSRFRVIGS LSNSKEFSEH 720
FRCPPGSPMN PPHKCEVW 738 
Gene Ontology
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR000718; Peptidase_M13.
 IPR018497; Peptidase_M13_C.
 IPR008753; Peptidase_M13_N. 
Pfam
 PF01431; Peptidase_M13
 PF05649; Peptidase_M13_N 
SMART
  
PROSITE
  
PRINTS
 PR00786; NEPRILYSIN.