UniProt Accession

 TM59L_HUMAN; Q9UK28 

Genbank Protein ID

 AF186264; BC010446 

Genbank Nucleotide ID

 AAF00529.1; AAH10446.1 

Protein Name

 Transmembrane protein 59-like 

Protein Synonyms/Alias

 Brain-specific membrane-anchored protein 

Gene Name

 TMEM59L 

Gene Synonyms/Alias

 BSMAP; C19orf4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
336	SLPPYKLKLDLTKL*	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. 

Sequence Annotation

 MOTIF 340 342 Microbody targeting signal (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:ProtInc. 

Interpro

 IPR022065; Uncharacterised_TMEM59. 

Pfam

 PF12280; BSMAP 

SMART

  

PROSITE

  

PRINTS