CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016841
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uveal autoantigen with coiled-coil domains and ankyrin repeats 
Protein Synonyms/Alias
 Nuclear membrane-binding protein; Nucling 
Gene Name
 Uaca 
Gene Synonyms/Alias
 Kiaa1561 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1134NGTIEQLKEELRSKQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. 
Sequence Annotation
 REPEAT 69 98 ANK 1.
 REPEAT 102 131 ANK 2.
 REPEAT 135 164 ANK 3.
 REPEAT 168 197 ANK 4.
 REPEAT 201 230 ANK 5.
 REPEAT 234 263 ANK 6.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 453 453 Phosphothreonine.  
Keyword
 Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1411 AA 
Protein Sequence
MKSLKSRLWK QDAPGPTSPS SPTAVASTQS AEWNKYDDRL MKAAERGDVE KVSSILAKKG 60
VHPGKLDVEG RSAFHVVASK GNLECLNAIL THGIDVATRD SAGRNALHLA AKYGHALCLQ 120
KLLQYNCPTE HVDLQGRTAL HDAVMADCPS SIQLLCDHGA SVNAKDIDGR TPLVLATQMC 180
RPTICQLLID RGADVNSRDK QNRTALMLGC EYGCRDAVEV LVKNGADLTL LDALGHDSSY 240
YARIGDNLDI LNLLKTASEN TNKGRELWRK GPPLQQRNLS HTQDEGSVKS TQREQREPHS 300
FQDLEIENED LREKLRKIQQ EQRILLDKVN GLQLQLNEEV MVADDLESER EKPKSLLAAK 360
EKQHEESLRT IEALKNRFKY FESDHPGPGS YPSNRKEDML HKQGQMYTTE PQCASPGIPP 420
HMHSRSMLRP LELSLPSQTS YSENEILKKE LETLRTYYDS AKQDRLKFQN ELAHKVAECK 480
ALALECERVK EDSDEQIKQL EDALKDVQKR MYESEGKVKQ MQTHFLALKE HLTNEAATGS 540
HRIIEELREQ LKDLKGKYEG ASAEVGKLRS QIKQSEMLVG EFKRDEGRLV EENKRLQKEC 600
GTCEVELERR GRRVVELEGQ LKELGAKLAL SVPTEKFESM KSSLSNDINE KVKRLAEVGR 660
DYESAQGEIR QLKRDLESVR AQHIRPEEHE QLRSRLEQKS GELGKKVSEL TLKNQTLQKD 720
VEKLHADNKL LNQQVHSLTV EMKTRYVPLR VSEEMKRSHD VNVEDLNKKL SEATQRYAEK 780
KQEAERLLAE NDKLTKNVSR LEAVFVAPEK HEKELMGLKS NIAELKKQLS ELNKKCGEGQ 840
EKIRALMSEN SSLKKTLSSQ YVPAKTHEEV KASLNSTVEK TNRALLEAKK RFDDTSQEVS 900
KLRDENEVLR RNLENVQNQM KADYVSLEEH SRRMSTVSQS LKEAQEANAA ILADHRQGQE 960
EIVSLHAEIK AQKKELDTIQ ECIKLKYAPL ARLEECERKF KATEKGLKEQ LSEQTHKCRQ 1020
RDEEVKKGKQ ENERLRADLA ALQKELQDRN ALAEEAREAE RALSGKADEL SKQLKDLSQK 1080
YSDVKSEREK LVEEKAKQAS EILAAQNLLQ KQPVPLEQVE ALKKSLNGTI EQLKEELRSK 1140
QRCLEREQQT VSQLQQLLEN QKNSSVTLAE HLKLKEALEK EVGIMKASLR EKEEESQKKT 1200
KEVSKLQTEV QTTKQALKNL ETREVVDMSK YKATKNDLET QISNLNDKLA SLNRKYDQAC 1260
EEKVSAKDEK ELLHLSIEQE IRDQKERCDK SLTTIMELQQ RIQESAKQIE AKDNKITELL 1320
NDVERLKQAL NGLSQLTYSS GSPTKRQSQL VDTLQQRVRD LQQQLADADR QHQEVIAIYR 1380
THLLSAAQGH MDEDVQAALL QIIQMRQGLV C 1411 
Gene Ontology
 GO:0043293; C:apoptosome; IDA:MGI.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:MGI.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IMP:MGI.
 GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
 GO:0042307; P:positive regulation of protein import into nucleus; IMP:MGI.
 GO:0009411; P:response to UV; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000727; T_SNARE_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50192; T_SNARE 
PRINTS
 PR01415; ANKYRIN.