| Tag | Content |
|---|
| CPLM ID | CPLM-009370 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-2,8-sialyltransferase 8F |
Protein Synonyms/Alias | Sialyltransferase 8F; SIAT8-F; Sialyltransferase St8Sia VI; ST8SiaVI |
Gene Name | ST8SIA6 |
Gene Synonyms/Alias | SIAT8F |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | NPSIITLKYGNLKEK | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity). |
Sequence Annotation | CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
CARBOHYD 93 93 N-linked (GlcNAc...) (Potential).
CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).
CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
DISULFID 186 335 By similarity. |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 398 AA |
Protein Sequence | MRPGGALLAL LASLLLLLLL RLLWCPADAP GRARILVEES REATHGTPAA LRTLRSPATA 60
VPRATNSTYL NEKSLQLTEK CKNLQYGIES FSNKTKGYSE NDYLQIITDI QSCPWKRQAE 120
EYANFRAKLA SCCDAVQNFV VSQNNTPVGT NMSYEVESKK EIPIKKNIFH MFPVSQPFVD 180
YPYNQCAVVG NGGILNKSLC GTEIDKSDFV FRCNLPPTTG DVSKDVGSKT NLVTINPSII 240
TLKYGNLKEK KALFLEDIAT YGDAFFLLPA FSFRANTGTS FKVYYTLEES KARQKVLFFH 300
PKYLKDLALF WRTKGVTAYR LSTGLMITSV AVELCKNVKL YGFWPFSKTV EDIPVSHHYY 360
DNKLPKHGFH QMPKEYSQIL QLHMKGILKL QFSKCEVA 398 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0030173; C:integral to Golgi membrane; IEA:InterPro. GO:0008373; F:sialyltransferase activity; ISS:BHF-UCL. GO:0016051; P:carbohydrate biosynthetic process; ISS:BHF-UCL. GO:0001574; P:ganglioside biosynthetic process; ISS:BHF-UCL. GO:0009311; P:oligosaccharide metabolic process; ISS:BHF-UCL. GO:0043687; P:post-translational protein modification; TAS:Reactome. GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. GO:0006493; P:protein O-linked glycosylation; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |