UniProt Accession

 CXB2_MOUSE; Q00977 

Genbank Protein ID

 M81445; M63803; BC013634; BC051437 

Genbank Nucleotide ID

 AAA37495.1; AAA37276.1; AAH13634.1; AAH51437.1 

Protein Name

 Gap junction beta-2 protein 

Protein Synonyms/Alias

 Connexin-26; Cx26 

Gene Name

 Gjb2 

Gene Synonyms/Alias

 Cxn-26 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
112	KFMKGEIKNEFKDIE	ubiquitination	[1]
116	GEIKNEFKDIEEIKT	ubiquitination	[1]
122	FKDIEEIKTQKVRIE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 

Sequence Annotation

 DISULFID 53 180 By similarity.
 DISULFID 60 174 By similarity.
 DISULFID 64 169 By similarity.  

Keyword

 Cell junction; Cell membrane; Complete proteome; Disulfide bond; Gap junction; Hearing; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0005243; F:gap junction channel activity; IDA:MGI.
 GO:0007267; P:cell-cell signaling; IDA:MGI.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW. 

Interpro

 IPR000500; Connexin.
 IPR002268; Connexin26.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.
 PR01139; CONNEXINB2.