| Tag | Content |
|---|
| CPLM ID | CPLM-018488 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U6 snRNA phosphodiesterase |
Protein Synonyms/Alias | |
Gene Name | Usb1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 260 | VRCKSGNKFFSMPLK | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (By similarity). |
Sequence Annotation | ACT_SITE 122 122 Proton donor/acceptor (By similarity).
ACT_SITE 210 210 Proton donor/acceptor (By similarity). |
Keyword | Complete proteome; Hydrolase; mRNA processing; mRNA splicing; Nuclease; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 267 AA |
Protein Sequence | MSSAPLVGYS SSGSEDEAEA VAAGRSKPGT GFHRCGQNPV PSEKLPVPDS VLSMFPSTEE 60
GPEDDSAKHG GRIRTFPHER GNWATHIYIP YEAKEDFRDL LDALLPRAQM FVPRLVLMEE 120
FHVSLSQSVV LRHHWILPFV QVLKDRMASF QRFFFTANRV KIYTNQEKTR TFIGLEVSSG 180
HAQFLDLVSE VDRAMKEFDL TTFYQDPSFH ISLAWCVGDA SLQLEGQCLQ ELQEIVDEFE 240
DSEMLLRVLA NQVRCKSGNK FFSMPLK 267 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |