UniProt Accession

 SURE_ECOLI; P0A840; P36664; Q2MA85 

Genbank Protein ID

 L07942; U29579; U00096; AP009048 

Genbank Nucleotide ID

 AAA79839.1; AAA69254.1; AAC75786.1; BAE76821.1 

Protein Name

 5'/3'-nucleotidase SurE 

Protein Synonyms/Alias

 Exopolyphosphatase; Nucleoside monophosphate phosphohydrolase; Stationary-phase survival protein SurE 

Gene Name

 surE 

Gene Synonyms/Alias

 ygbC; b2744; JW2714 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
21	PGIQTLAKALREFAD	acetylation	[1]
169	DLPLDQIKGIRVTRC	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase. 

Sequence Annotation

 METAL 8 8 Divalent metal cation (By similarity).
 METAL 9 9 Divalent metal cation (By similarity).
 METAL 39 39 Divalent metal cation (By similarity).
 METAL 92 92 Divalent metal cation (By similarity).  

Keyword

 Cobalt; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Nickel; Nucleotide-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008254; F:3'-nucleotidase activity; IDA:EcoCyc.
 GO:0008253; F:5'-nucleotidase activity; IDA:EcoCyc.
 GO:0004309; F:exopolyphosphatase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0006464; P:cellular protein modification process; IMP:EcoCyc. 

Interpro

 IPR002828; SurE-like_Pase/nucleotidase. 

Pfam

 PF01975; SurE 

SMART

  

PROSITE

  

PRINTS