UniProt Accession

 DHI2_MOUSE; P51661; Q91WK3 

Genbank Protein ID

 S79554; S79550; S79551; S79552; S79553; X90646; X90647; BC014753 

Genbank Nucleotide ID

 AAC60711.1; AAC60711.1; AAC60711.1; AAC60711.1; AAC60711.1; CAA62218.1; CAA62219.1; AAH14753.1 

Protein Name

 Corticosteroid 11-beta-dehydrogenase isozyme 2 

Protein Synonyms/Alias

 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase 

Gene Name

 Hsd11b2 

Gene Synonyms/Alias

 Hsd11k 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	GCDTGFGKETAKKLD	ubiquitination	[1]
133	DLCSPRLKLLQMDLT	ubiquitination	[1]
141	LLQMDLTKAEDISRV	ubiquitination	[1]
278	TNVNLWEKRKQLLLA	ubiquitination	[1]
280	VNLWEKRKQLLLANI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. 

Sequence Annotation

 NP_BIND 82 111 NAD (By similarity).
 ACT_SITE 232 232 Proton acceptor (By similarity).
 BINDING 219 219 Substrate (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Microsome; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0003845; F:11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; IEA:Compara.
 GO:0051287; F:NAD binding; IEA:Compara.
 GO:0005496; F:steroid binding; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0002017; P:regulation of blood volume by renal aldosterone; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032094; P:response to food; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.