UniProt Accession

 PIP21_ARATH; P43286 

Genbank Protein ID

 X75883; AL132966; CP002686; CP002686; AY039579; AY044327; AY056085; AF428426; AY072374; AY087854 

Genbank Nucleotide ID

 CAA53477.1; CAB67649.1; AEE79083.1; AEE79084.1; AAK62634.1; AAK73268.1; AAL06973.1; AAL16195.1; AAL62366.1; AAM65406.1 

Protein Name

 Aquaporin PIP2-1 

Protein Synonyms/Alias

 Plasma membrane intrinsic protein 2-1; AtPIP2;1; Plasma membrane intrinsic protein 2a; PIP2a 

Gene Name

 PIP2-1 

Gene Synonyms/Alias

 PIP2A; At3g53420; F4P12.120 

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKDVEAVPG	methylation	[1, 2]

Reference

 [1] O-carboxyl- and N-methyltransferases active on plant aquaporins.
 Sahr T, Adam T, Fizames C, Maurel C, Santoni V.
 Plant Cell Physiol. 2010 Dec;51(12):2092-104. [PMID: 21062871]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Water channel required to facilitate the transport of water across cell membrane. Probably involved in root water uptake. Its function is impaired by Hg(2+). 

Sequence Annotation

 MOTIF 107 109 NPA 1.
 MOTIF 228 230 NPA 2.
 MOD_RES 3 3 N6,N6-dimethyllysine; partial.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 283 283 Phosphoserine.  

Keyword

 Cell membrane; Complete proteome; Membrane; Methylation; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0009507; C:chloroplast; IDA:TAIR.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:TAIR.
 GO:0009506; C:plasmodesma; IDA:TAIR.
 GO:0005773; C:vacuole; IDA:TAIR.
 GO:0015250; F:water channel activity; IDA:TAIR.
 GO:0080170; P:hydrogen peroxide transmembrane transport; IDA:TAIR.
 GO:0009737; P:response to abscisic acid stimulus; IDA:TAIR.
 GO:0009414; P:response to water deprivation; IEP:TAIR. 

Interpro

 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR00783; MINTRINSICP.